高血压舒张功能不全患者左室心肌收缩同步性的分析-analysis of left ventricular systolic synchronization in patients with hypertension diastolic dysfunction.docxVIP

福建医科大学 福建医科大学 2008 级硕士学位论文 PAGE PAGE 7 velocities(Sa, Ea, Aa) .The dynamic images stored in hardware were analysised by EchoPAC 7.0 workstation offline and left ventricular synchrony parameters were achieved..The left ventricular synchrony parameters included 2-dimensional strain echocardiography(2DSE)parameters and tissue synchronization imaging (TSI)parameters .The time from the onset of QRS complexes to systole peak strain from the longitudinal,radial vectors(Tls,Trs)was recorded and measured using 2DSE respectively.The mean and the standard deviation of Tls，Trs of 12 segments were calculated as indicator of LV systolic synchrony.Time to peak systolic velocity (Ts) of 12 segments was obtained in apical 4-chamber view,apical 2-chamber view and long axis of left ventricular view using TSI. The mean,standard deviation and the max difference of Ts were calculated.These parameters were used to assess the systolic synchrony of left ventricle. Results LV mass and left atrial volume increased in the HT-HFP patients and left ventricular ejection fraction(LVEF) and Sa slightly decreased [（HT-HFP: 62.12±6.31）%vs(NC:64.08±4.39)%，p＜0.05；(HT-HFP :0.05±0.01） vs (NC:0.06±0.01),p＜0.05]. Those parameters of LVH group was lower than those of NLVH group. Both 2DSE and TSI can show that the time to peak of longitudinal strain or velocity and the longitudinal synchrony index of these times in the HT-HFP group were higher than those in NC group（all p 0.05）,and no significant difference was found between the LVH group and the NLVH group（p＞ 0.05）.The longitudinal dyssynchrony index had negative correlation with Sa （p 0.05）and positive correlation with LVMI（r=0.249，p0.05）. Prolonged the mean of time to LV radial strain in the HT-HFP patients（p 0.05）,but no significant difference was found between the LVH group and the NLVH group（p＞0.05）. Conclusions Left ventricular longitudinal systolic dyssynchrony was found in hypertensive patients with diastolic dysfunction and with th