肿瘤转移抑制基因kai1 mmp2在乳腺癌中的表达及临床意义-expression of tumor metastasis suppressor gene kai 1 mmp 2 in breast cancer and its clinical significance.docxVIP

下载本文档

5
0
约4.26万字
约 46页
2018-09-09 发布于上海
举报
版权申诉

肿瘤转移抑制基因kai1 mmp2在乳腺癌中的表达及临床意义-expression of tumor metastasis suppressor gene kai 1 mmp 2 in breast cancer and its clinical significance.docx

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

肿瘤转移抑制基因kai1 mmp2在乳腺癌中的表达及临床意义-expression of tumor metastasis suppressor gene kai 1 mmp 2 in breast cancer and its clinical significance

河南科技大学大学硕士学位论文结论：KAI1 和 MMP-2 在乳腺癌中的表达与临床分期、组织学分级、淋巴有无转移及病理类型相关，KAI1 表达下降和 MMP-2 表达升高促进乳腺癌的侵袭与转移；KAI1 和 MMP-2 在乳腺癌中的表达呈负相关，提示它们可能共同参与了乳腺癌的进展并存在内在联系，联合检测二者的表达对乳腺癌的侵袭和转移能力及预后评估具有一定的临床参考价值；关键词：乳腺癌，KAI1，MMP-2，侵袭与转移，免疫组化论文类型：应用基础研究 II 摘要 Subject: Expression and clinical significance of tumor metastasis suppressor gene KAI1 and MMP-2 in breast cancer Specialty: Oncology Name: Yang Junchuan Supervisor: Professor Liu Jinbiao ABSTRACT Objective: To study the expression and clinical significance of tumor metastasis suppressor gene KAI1 and MMP-2 in breast cancer. Methods: The expression of KAI1 and MMP-2 were detected by immunohistochemistry in 75 specimens of breast cancer tissue and 14 specimens of benign breast diseases tissue and its relationship with pathological type, clinical stage, histological grade, metastasis of axillary lymph nodes, tumor size, patients age and menopause were analyzed. Results (1) The positive expression rate of KAI1 in 75 cases of breast cancer was 46.7%(35/75), respectively, which was significantly lower than in benign breast diseases(78.6%)（P0.05）. The positive rate of them had significantly difference. The positive rate was 34.8%(16/46) in the group with metastasis of axillary lymph nodes and it was 65.5%(19/29) in the group without metastasis on the other hand. The positive rate of them had significantly difference. The positive rate was 73.3%(11/15) in the group of intraductal carcinoma and it was 40%(24/60) in the group of infiltrating ductal carcinoma. With the clinical stage and histological grade increasing, the expression of KAI1 in breast cancer decreased gradually（P0.05）. The expression of KAI1 was not associated with tumor size，menopause and the patients age, but associated with clinical stage, histological grade, metastasis of axillary lymph node and pathological type. (2) The positive expression rate of MMP-2 in 75 cases of breast cancer was 64%（48/75）, which was significan