急性缺血性脑卒中患者行动脉溶栓和静脉溶栓临床效果对比研究.docVIP

急性缺血性脑卒中患者行动脉溶栓和静脉溶栓临床效果对比研究 　　【摘要】 目的：观察动脉溶栓和静脉溶栓治疗急性缺血性脑卒中的临床疗效。方法：选取本院2015年8月-2016年7月期间收治的74例急性缺血性脑卒中患者作为研究对象，随机分为观察1组和观察2组，每组各37例。观察1组给予阿替普酶动脉溶栓治疗，观察2组给予阿替普酶静脉溶栓治疗，比较两组患者的治疗效果。结果：两组患者治疗后24 h、1周、2周的NIHSS（脑卒中量表）评分比较差异均无统计学意义（P0.05）。观察1组患者的疾病治疗总有效率为94.6%，与观察2组患者的91.9%比较差异无统计学意义（P0.05）。治疗后3个月，两组患者的血管再通率、病死率比较差异均无统计学意义（P0.05）。结论：对急性缺血性脑卒中患者实施动脉溶栓治疗和静脉溶栓治疗均可获得确切疗效。 　　【关键词】 急性缺血性脑卒中； 动脉溶栓； 静脉溶栓； 血管再通率； 病死率 　　【Abstract】 Objective：To observe the clinical effect of arterial thrombolysis and intravenous thrombolysis in the treatment of acute ischemic stroke.Method：A total of 74 patients with acute ischemic stroke who were admitted to our hospital from August 2015 to July 2016 were randomly divided into two groups，observation group 1 and observation group 2，37 cases in each group.The observation group 1 was given Alteplase arterial thrombolysis，while the observation group 2 was given Alteplase intravenous thrombolysis，the treatment results of two groups were compared.Result：There was no significant difference in the scores of NIHSS （Stroke Scale） between the two groups at 24 h，1 week and 2 weeks after treatment（P0.05）.The total effective rate of observation group 1 was 94.6%，the observation group 2 of that was 91.9%，the difference was no statistically significant（P0.05）.There were no significant difference in the rate of recanalization and mortality of two groups （P0.05）.Conclusion：For acute ischemic stroke patients with arterial thrombolytic therapy and intravenous thrombolytic therapy can obtain exact curative effect. 　　【Key words】 Acute ischemic stroke； Arterial thrombolysis； Intravenous thrombolysis； Vascular recanalization rate； Mortality 　　First-author’s address：Gaozhou People’s Hospital，Gaozhou 525200，China 　　doi：10.3969/j.issn.1674-4985.2017.34.009 　　缺血性?X卒中的发病数量占脑卒中患者总发病数量的60%～70%，其中绝大多数患者为急性缺血性脑卒中患者，起病骤急、病情进展快，预后不佳，需要立即接受溶栓治疗，以缩小脑组织梗死面积[1-3]。阿替普酶为我国临床治疗脑卒中患者常用的一种血栓溶解药，有静脉给药、动脉给药两种治疗方式[4-5]。本研究对该药物动脉溶栓和静脉溶栓治疗急性缺血性脑卒中患者的临床疗效进行对比分析，旨在明确该疾病患者的最佳溶栓治疗方案，现报道如下。