慢性阻塞性肺疾病急性加重期C―反应蛋白及降钙素原临床诊断价值.docVIP

慢性阻塞性肺疾病急性加重期C―反应蛋白及降钙素原临床诊断价值 　　[摘要] 目的 探讨慢性阻塞性肺疾病急性加重期C-反应蛋白及降钙素原的临床诊断价值。方法 收集2015年1月～2016年1月期间在我院治疗的慢性阻塞性肺疾病急性加重期患者71例作为研究组，收集同一时间在我院治疗的慢性阻塞性肺疾病稳定期患者50例作为对照组，将71例慢性阻塞性肺疾病急性加重期患者再次分为两组，感染组31例，非感染组40例，检测所有患者C-反应蛋白（CRP）及降钙素原（PCT）、FEV1/FVC和FEV1%、死亡率。结果 研究组CRP、PCT与对照组比较更高，FEV1%、FEV1/FVC（%）与对照组比较均更低，死亡率与对照组比较更高，两组差异有统计学意义（P0.05）。感染组CRP、PCT与非感染组比较更高，FEV1%、FEV1/FVC（%）与非感染组比较更低，死亡率与非感染组比较更高，两组差异有统计学意义（P0.05）。 结论 在慢性阻塞性肺疾病急性加重期CRP和PCT有重要的临床诊断价值，急性加重期的CRP、PCT均较高，慢性阻塞性肺疾病急性加重期感染患者CRP、PCT水平较高。 　　[关键词] 慢性阻塞性肺疾病；急性加重期；C-反应蛋白；降钙素原 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1673-9701（2017）07-0016-03 　　[Abstract] Objective To explore the clinical diagnostic value of C-reactive protein and procalcitonin in acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A total of 71 patients with acute exacerbation of chronic obstructive pulmonary disease who were treated in our hospital from January 2015 to January 2016 were selected as the study group. 50 patients with stable COPD who were treated in our hospital at the same time were collected as the control group. Then the 71 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into two groups including the infection group with 31 cases and the non-infection group with 40 cases. C-reactive protein（CRP）， procalcitonin （PCT）， FEV1/FVC， FEV1%， and mortality were measured in all patients. Results The CRP and PCT of the study group were higher than those of the control group， while the FEV1% and FEV1/FVC（%） in the study group were lower than those in the control group. And the mortality rate in the study group was higher than that of the control group. The difference between the two groups was statistically significant（P0.05）. The CRP and PCT of the infection group were higher than those in the non-infected group. FEV1%， FEV1/FVC（%） of the infection group were lower than those in the non-infected group. And the mortality rate in the infection group was higher than that of the non-infected gro