持续冲洗辅助关节镜对膝骨性关节炎sod no水平影响的动物实验及临床分析-animal experiment and clinical analysis of the effect of continuous washing assisted arthroscopy on sod no level in knee osteoarthritis.docxVIP

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持续冲洗辅助关节镜对膝骨性关节炎sod no水平影响的动物实验及临床分析-animal experiment and clinical analysis of the effect of continuous washing assisted arthroscopy on sod no level in knee osteoarthritis.docx

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持续冲洗辅助关节镜对膝骨性关节炎sod no水平影响的动物实验及临床分析-animal experiment and clinical analysis of the effect of continuous washing assisted arthroscopy on sod no level in knee osteoarthritis

II II 胞数量明显减少、杂乱，软骨表层有血管生成。临床实验结果：①关节液中SOD、NO：在术后1周时，持续冲洗组关节液中SOD的活力明显高于非持续冲洗组（P﹤0.05）。且两组在术后1周时关节液中SOD的活力也高于术前SOD活力（P﹤0.01）;同时持续冲洗组和非持续冲洗组在术后1周时NO浓度水平下降明显，与术前有显著差异性（P﹤0.05），且两组之间在术后1周时也有明显的差异性（P﹤0.05）。②疗效评分：在术后第1周时，持续冲洗组和非持续冲洗组的评分无差异，到第2周时，持续冲洗组评分结果要明显高于非持续冲洗组评分（P﹤0.05），两组评分也明显高于术前评分（P﹤ 0.05）。结论 ①关节腔持续冲洗能够明显改善OA关节内细胞因子的含量。经过对兔膝OA持续冲洗及临床患者膝OA行关节镜术后给予持续冲洗，关节内 SOD、NO都有了不同程度的改变，减轻了细胞因子对关节软骨的破坏。② 膝关节镜术后的持续冲洗能明显减轻膝OA患者的症状。通过膝关节镜手术的治疗，消除了关节内的有害因素，再经术后的持续冲洗，进一步改善关节内细胞因子及冲走手术所带来的出血、碎屑，提高膝关节镜的疗效。③NO 的敏感性要明显优于SOD。相同时间段内，NO的变化幅度要明显优于SOD，说明NO在OA的病情变化过程中要敏感于SOD，因此，NO可以作为监测OA 疾病发展变化的首选指标。关键词关节持续冲洗，骨关节炎，一氧化氮，过氧化物岐化酶 III III CONTINUE IRRIGATION AFTER ARTHROSCOPY IMPACT THE KNEE OA ON SOD, NO LEVELS IN ANIMAL EXPERIMENT AND CLINICAL RESEARCH ABSTRACT Objective to study the impact to osteoarthritis SOD and NO level and the curative effect of the continual irrigation after arthroscopy operation to the knee OA patients,and supply the fundation of the theory for relieving knee osteoarthritis patients’ ache during the early time after arthroscope operation and improving knuckle function. Methods Animal experiment:eighteen experimental rabbits to make bilateral knee OA model in Hulth way.Later one month after operation , four of 18 rabbits were extracted at random to judge whether the operation succeed or not.And then,the other fourteen experimental rabbits were divided into two groups.One group of the rabbits were irrigated on bilateral knees with 500mlsaline at room temperature for 4 hours at the first and eighth day, as irrigation group. The other group of the rabbits were not irrigated ,and as non-irrigation group.All experimental rabbits were killed one week later after the irrigation and then examined the vitality of SOD,and the content of NO of bilateral knee synovium.At the same time,knee weight-bearing area of articular cartilage was dyed with HE,to observe the histology change of specimen under light microscope.Clinic trial: Forty diagosed patients with knee OA we