早期大剂量阿托伐他汀对缺血性脑卒中患者血脂hs―CRP影响.docVIP

早期大剂量阿托伐他汀对缺血性脑卒中患者血脂hs―CRP影响 　　[摘要] 目的 研究早期大剂量应用阿托伐他汀对缺血性脑卒中患者血脂、高敏C-反应蛋白（hs-CRP）的影响。 方法 随机选取2012年2月～2013年2月在本院接受治疗的90例缺血性脑卒中患者，将其随机分为对照组和观察组，每组45例。对照组应用常规治疗方法，且早期服用阿托伐他汀10 mg/d进行治疗，观察组早期服用阿托伐他汀20 mg/d进行治疗。观察两组患者治疗前和治疗2周后血脂、hs-CRP水平的变化，同时观察患者住院期间脑血管病事件的发生情况。 结果 观察组短暂性脑缺血发作（TIA）发生率低于对照组，差异有统计学意义（P0.05）。治疗后观察组患者的总胆固醇（TC）、甘油三酯（TG）、hs-CRP和低密度脂蛋白胆固醇（LDL-C）水平明显低于对照组，差异有统计学意义（P0.05）。 结论 早期大剂量应用阿托伐他汀可以明显降低缺血性脑卒中患者的血脂、hs-CRP水平，抑制???症因子，更有效地降低患者的致残、致死率，对于临床具有重大意义。 　　[关键词] 阿托伐他汀；缺血性脑卒中；血脂；高敏C-反应蛋白；低密度脂蛋白胆固醇 　　[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721（2015）02（b）-0141-03 　　The influence of early large dose atorvastatin on the lipids and hs-CRP of patients with ischemic stroke 　　ZHUANG Xue-fen1 LIN Gui-de2 　　1.Department of Neurology，the Second People′s Hospital of Longgang District in Shenzhen City，Shenzhen 518100，China；2.Department of Medical，the Second People′s Hospital of Longgang District in Shenzhen City，Shenzhen 518100，China 　　[Abstract] Objective To investigate the influence of early large dose atorvastatin on the lipids and hs-CRP of patients with ischemic stroke. Methods 90 cases of patients with ischemic stroke treated in our hospital from February 2012 to February 2013 were randomly chosen as the research objects，and were randomly divided into control group and observation group，45 patients in each group.The control group were given with conventional treatment and early treatment with atorvastatin 10 mg/d treatment，the observation group was given with early atorvastatin treatment，20 mg/d.The lipids and high-sensitivity C-reactive protein （hs-CRP） of the two groups was observed before and after 2 weeks treatment，and the events during cerebrovascular disease inpatients was observed. Results The incidence of transient ischemic attack （TIA） rate in the observation group was lower than that in the control group，the difference was significant （P0.05）.After treatment，the total cholesterol （TC），triglyceride （TG），low-density lipoprotein cholesterol （LDL-C） and hs-CRP