桂枝茯苓丸加减对提高肺癌手术效果对比研究.docVIP

桂枝茯苓丸加减对提高肺癌手术效果对比研究 　　[摘要] 目的 探讨桂枝茯苓丸加减在提高肺癌手术效果中的作用。方法 随机选取2015年1月―2017年2月该院收治的100例肺癌患者为研究对象，依据治疗方式将入选病例分为两组。对照组50例，单纯予以患者肺癌根治术；实验组50例，患者先口服中草药合剂桂枝茯苓丸，疗程结束后再予以肺癌根治术。观察两组手术指标、临床症状改善情况、围术期并发症、术后化疗毒副反应及生存率。结果 实验组手术时间（168.5±22.1）min，术中出血量（247.7±61.8）mL，淋巴清扫数（9.8±2.0）个，置管引流时间（5.5±2.1）d，术后住院时间（13.6±2.9）d，术后并发症发生率6.0%，与对照组比较差异无统计学意义（P0.05）。实验组治疗总有效率88.0%，化疗期间不良反应发生率78.0%，随访期间生存率80.0%，各项指标均优于对照组，差异有统计学意义（P0.05）。结论 桂枝茯苓丸加减可有效提高肺癌手术效果，改善患者临床症状，减少术后化疗不良反应，提高生存率，值得推广使用。 　　[关键词] 肺癌；桂枝茯苓丸；加减治疗；肺癌根治术 　　[中?D分类号] R285 [文献标识码] A [文章编号] 1674-0742（2017）11（a）-0160-03 　　[Abstract] Objective To study the effect of modified guizhi fuling pill in improving the operative effect of lung cancer. Methods 100 cases of lung cancer patients admitted and treated in our hospital from January 2015 to February 2017 were random and divided into two groups with 50 cases in each according to different treatment methods， the control group adopted the simple radical resection of pulmonary carcinoma， while the experimental group took the modified guizhi fuling pill orally first， and then were treated with radical resection of pulmonary carcinoma， and the operation indexes， improvement of clinical symptoms， complications during the perioperative period and toxic and side effect and survival rate of the two groups were observed. Results The operation time， intraoperative bleeding amount， lymph node dissection number， catheter drainage time， postoperative length of stay， incidence rate of postoperative complications in the experimental group were respectively （168.5±22.1）min， （247.7±61.8）mL， （9.8±2.0）， （5.5±2.1）d， （13.6±2.9）d， 6.0%， and the differences between groups were not statistically significant（P0.05）， and the total effective rate， incidence rate of toxic and side effect and survival rate during the follow-up in the experimental group were respectively 88.0%，78.0% and 80.0%， and the differences were statistically significant（P0.05）. Conclusion The modified guizhi fuling pill can effectively impro