氨基末端B型利钠肽与超声心动图在心力衰竭病因中价值.docVIP

氨基末端B型利钠肽与超声心动图在心力衰竭病因中价值 　　doi：10.3969/j.issn.1007-614x.2014.19.66 　　摘 要 目的：探讨超声心动图心脏结构异常的心脏病心力衰竭患者与氨基末端B型利钠肽（NT-proBNP）的相关性及临床价值，对病情预后进行评估。方法：2012年1月-2014年5月收治心力衰竭（HF）患者800例，比较分析不同患者的氨基末端B型利钠肽（NT-proBNP）水平与超声心动图显示心脏结构异常之间的相关性，并且评估患者的预后情况。结果：血浆NT-proBNP的水平与患者的心功能不全呈正相关关系，心衰的程度越严重，NT-proBNP的水平越高（P0.05），并且血浆NT-proBNP值与LVEF呈显著负相关（P0.05）。结论：血浆NT-proBNP的水平与患者心力衰竭程度有相关性，可以作为心衰的诊断标准。 　　关键词 氨基末端B型利钠肽 超声心动图 心力衰竭 　　Investigation of the value of amino terminal B type natriuretic peptide and ultrasonic heartbeat diagram in the pathogeny of heart failure 　　Li Daxiang，Fang Feiying，Wei Yunzhen，Liu Guosheng，Zhang Zhiwei 　　Internal Medicine and Pediatrics，the Public Hospital of Zhongshan City，Guangdong 528441 　　Abstract Objective：To explore the relationship of heart failure patients with abnormal cardiac structure in ultrasonic heartbeat diagram and NT-proBNP and clinical significance，to evaluate the prognosis of the disease.Methods：800 cases with heart failure were selected from January 2012 to May 2014.We compared and analyzed the relationship of heart failure patients with abnormal cardiac structure in ultrasonic heartbeat diagram and NT-proBNP in different patients and evaluated the prognosis of the disease.Results：Through the experiment，the levels of plasma NT-proBNP had positive correlation with the heart function in patients with heart failure.The more serious of the degree of heart failure，the higher of the level of NT-proBNP（P0.05）.Moreover，the plasma NT-proBNP level was negatively correlated with LVEF（P0.05）.Conclusion：There is a correlation between the level of plasma NT-proBNP and degree of heart failure，and it can be used as diagnostic standard of heart failure. 　　Key words The amino terminal B type natriuretic peptide；Ultrasonic heartbeat diagram；Heart failure 　　随着经济水平的提高，人们的生活习惯也随着发生改变，心脏疾病也越来越多，心力衰竭就是其中常见的一种[1]。引起心衰的原因有很多，例如冠心病、高血压、瓣膜病、心肌病、肺心病等都可以继发心衰，心衰患者最典型的症状是出现不同程度的呼吸困难，并且在进行活动时加重，严重的患者可出现端坐呼吸、咳嗽并伴大量白色绒粉红色泡沫痰、食欲降低、双下肢浮肿等表现[2]。对于心衰的诊断，临床上比较常用的检查就是超声心动图，