氨基末端B型脑钠肽前体高敏C反应蛋白与脾肾阳虚型慢性心力衰竭相关性探讨.docVIP

氨基末端B型脑钠肽前体高敏C反应蛋白与脾肾阳虚型慢性心力衰竭相关性探讨 　　[摘要] 目的：探讨氨基末端B型脑钠肽前体（NT-proBNP）、高敏C反应蛋白（hs-CRP）与脾肾阳虚型慢性心力衰竭的相关性，为脾肾阳虚型慢性心力衰竭的中医证型提供客观依据。方法：将入选的180例慢性心力衰竭患者进行中医辨证分型，分为脾肾阳虚型90例与非脾肾阳虚型90例两组，两组分别测定NT-proBNP、高敏C反应蛋白（hs-CRP）水平。结果：脾肾阳虚型慢性心力衰竭组患者的NT-proBNP、hs-CRP水平与非脾肾阳虚型组患者比较，差异均有高度统计学意义（均P0.01）。结论：NT-proBNP、hs-CRP可以作为评价脾肾阳虚型慢性心力衰竭的客观性指标，并具有临床可行性。 　　[关键词] 氨基末端B型脑钠肽前体；高敏C反应蛋白；脾肾阳虚；慢性心力衰竭 　　[中图分类号] R541.6；R256.21 [文献标识码] A [文章编号] 1673-7210（2011）11（b）-031-02 　　 　　Correlation study of NT-proBNP, hs-CRP and spleen-kidney yang deficiency with chronic heart failure 　　XING Xiaobo, LIU Fusong, ZHANG Bingyin, LIU Xin, FAN Guanghong 　　Department of Cardiology, the Third People′s Hospital of Qingdao City, Shandong Province, Qingdao 266041, China 　　[Abstract] Objective: To investigate correlation of N-terminal portion of brain natriuretic (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and spleen-kidney yang deficiency of chronic heart failure (CHF), and to provide objective basis for spleen-kidney yang deficiency of symptoms and signs in traditional Chinese medicine. Methods: 180 patients with CHF were analyzed with symptoms and signs in traditional Chinese medicine. They were divided into spleen-kidney yang deficiency group (90 cases) and non-spleen-kidney yang deficiency group (90 cases), the levels of NT-proBNP and hs-CRP were measured. Results: The levels of NT-proBNP and hs-CRP in spleen-kidney yang deficiency group were compared with non-spleen-kidney yang deficiency group, there were significant differences between them (all P0.01). Conclusion: NT-proBNP and hs-CRP may be objectivity indexes for patients of spleen-kidney yang deficiency with chronic heart failure, and have clinical feasibility. 　　[Key words] NT-proBNP; hs-CRP; Spleen-kidney yang deficiency; Chronic heart failure 　　 　　 　　慢性充血性心力衰竭（CHF）是极为严重而常见的临床综合征，是各种心血管疾病的危重阶段。近年来，通过对心力衰竭患者进行氨基末端B型脑钠肽前体（NT-proBNP）、高敏C-反应蛋白（hs-CRP）等生物标志物进行检测及综合分析发现，NT-proBNP、hs-CRP的水平对心力衰竭诊断、严重程度评估和治疗有重要的指导意义。本文通过探讨NT-proBNP、hs-CRP