氨磺必利利培酮奋乃静对分裂症患者生活质量影响对照研究.docVIP

氨磺必利利培酮奋乃静对分裂症患者生活质量影响对照研究 　　[摘要] 目的 比较氨磺必利、利培酮、奋乃静对分裂症患者生活质量的影响。 方法 将2013年2月～2014年6月我院住院和门诊治疗的240例分裂症患者随机分为3组，分别给于氨磺必利、利培酮、奋乃静治疗8周。采用生活质量问卷（WHO.QOT-100），在治疗前，第2、4、8周末分别进行评定。 结果 氨磺必利组在第2周末生活质量总体分数及生理、心理、独立、社会领域分数均明显升高，与治疗前和另2组比较差异有统计学意义（P0.05），至第4周末3组中各分数均与治疗前比较差异有统计学意义（P0.01），氨磺必利组生活质量总体分数和生理领域分数与奋乃静组比较差异有统计学意义（P0.05），生理领域分持续到第8周末研究结束时差异有统计学意义（P0.05）。利培酮组第4周末生活质量总体分数和生理领域分数与奋乃静组比较差异有统计学意义（P0.05）。 结论 氨磺必利对提高分裂症患者生活质量效果最好、利培酮次之、奋乃静较差。 　　[关键词] 分裂症；氨磺必利；利培酮；奋乃静；生活质量 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2015）09（a）-0125-03 　　[Abstract] Objective To investigate the effect of amisulpride，risperidone and perphenazine on the quality of life in schizophrenia patients. Methods 240 schizophrenia patients in our hospital from June 2014 to February 2013 were randomly divided into 3 groups，which were treated with amisulpride，risperidone and perphenazine for 8 weeks respectively.The quality of life questionnaire（WHO.QOT-100） was measured by the end of 2，4，8 weeks. Results Compared with base line and the other group，the scores of quality of life，physiology，psychology，independent，social field increased significantly after a 2 weeks treatment in amisulpride，with statistical difference（P0.05）.Compared with base line，every date increased significantly after a 4 weeks treatment，with statistical difference （P0.01）.Compared with perphenazine，the scores of quality of life，physiology also increased significantly in amisulpride and risperidone，with statistical difference（P0.05），and the physiology scores significantly change continued to the end of the study in smisulpride，with statistical difference（P0.05）. Conclusion On improving the quality of life in schizophrenia patients，amisulpride is the best，the next is risperidone，the last is perphenazine. 　　[Key words] Schizophrenia；Amisulpride；Risperidone；Perphenazine；Quality of life 　　分裂症患者的生活质量由多种因素决定：症状缓解的快慢、缓解的程度、有无残留症状，是否能足够长时间坚持服药等，既与疾病本身有关，也与服用药物的疗效和不良反应密切相关。如何在众多药物之中选择起效快、不良反应少，特别是能更好提高患者生活质量的药物，是医生和患者都十分关注的问题。本研究选取临床中常用的氨磺必利、