氨磺必利与阿立哌唑治疗以阴性症状为主精神分裂症对照研究.docVIP

氨磺必利与阿立哌唑治疗以阴性症状为主精神分裂症对照研究 　　[摘要]目的 探?氨磺必利与阿立哌唑治疗以阴性症状为主精神分裂症的临床效果与安全性。方法 选取2017年5～12月我院收治的80例以阴性症状为主的精神分裂症患者作为研究对象，将其随机分为对照组和研究组，每组各40例。研究组患者口服氨磺必利片治疗，对照组患者口服阿立哌唑治疗，两组患者均治疗8周。比较两组患者治疗前和治疗2、4、8周后的治疗效果、阳性和阴性综合征量表（PANSS）评分及不良反应发生情况。结果 治疗8周后，研究组患者的治疗总有效率为76.92%，对照组患者的治疗总有效率为75.67%，两组患者的治疗总有效率比较，差异无统计学意义（P0.05）。治疗2周后，研究组患者的阴性因子评分明显低于治疗前及对照组，差异均有统计学意义（P0.05）。治疗4周后，两组患者的阴性因子评分均明显低于治疗前，差异有统计学意义（P0.05）。研究组患者不良反应发生率（41.02%）低于对照组（54.05%），差异有统计学意义（P0.05）。结论 氨磺必利治疗以阴性症状为主的精神分裂症的临床效果与采用阿立哌唑治疗相当，但氨磺必利起效快，不良反应少，更加安全，依从性好，值得推广应用。 　　[关键词]氨磺必利；阿立哌唑；阴性症状；精神分裂症 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2018）4（b）-0117-03 　　A controlled clinical study of Amisulpride and Aripiprazole in treatment of patients with negative symptoms of schizophrenia 　　WEI Li-qun 　　Department of Psychiatry，the Fourth People′s Hospital of Jingdezhen，Jiangxi Province，Jingdezhen 333000，China 　　[Abstract]Objective To compare the efficacy and safety between Amisulpride and Aripiprazole in the treatment of patients with negative symptoms of schizophrenia.Methods A total of 80 Patients with negative symptoms of schizophrenia from May to December in 2017 treated in our hospital were selected as the research objects，all the patients were randomly divided into the control group and the study group，40 cases in each group.In the study group，the patients were treated with oral Amisulpride Tablets，and patients in the control group were treated with oral Aripiprazole.Both groups were treated for 8 weeks.The therapeutic effect，the positive and negative syndrome scale （PANSS） scores and adverse reactions were compared between two groups of patients before and after treatment 2，4 and 8 weeks.Results After 8 weeks of treatment，the total efficiency of the study group was 76.92%，and the the total efficiency of the control group was 75.67%，there was no significant difference between the two groups （P0.05）.After 2 weeks of treatment，the negative factor score of the study group was significantly lower than before treatme