消痤颗粒对儿童重度痤疮血清白介素―2白介素―4干扰素―γ影响.docVIP

消痤颗粒对儿童重度痤疮血清白介素―2白介素―4干扰素―γ影响 　　[摘要] 目的 ?u价中药消痤颗粒治疗重度痤疮对血清白介素（IL）-2、IL-4、干扰素（IFN）-γ的影响，为临床提供依据。 方法 选取我院2013年12月～2015年12月收治的60例重度痤疮患儿作为本次研究对象，以随机数字表法分为常规西药治疗的对照组与西药治疗联合消痤颗粒治疗的观察组，每组各30例患者，2个月为1个疗程，两组均连续治疗2个疗程，检测两组治疗前、后外周血IL-2、IL-4、IFN-γ水平，并进行对比观察。 结果 在治疗总有效率方面，观察组与对照组分别为96.67%与83.33%，差异有统计学意义（P0.05）；治疗后，两组血清IL-4水平均较前明显下降，IL-2、IFN-γ较前明显升高，差异有统计学意义（P0.05）。在不良反应发生率方面，观察组与对照组分别为6.67%与16.67%，差异有统计学意义（P0.05）。 结论 中药消痤颗粒可有效治疗重度痤疮，可明显改善血清IL-2、IL-4、IFN-γ水平，对血清IL-2、IL-4、IFN-γ水平进行监测，可为临床评估病情及治疗效果提供依据。 　　[关键词] 重度痤疮；白介素2；白介素4；干扰素-γ；影响 　　[中图分类号] R285.5 [文献标识码] A [文章编号] 2095-0616（2017）14-21-04 　　Influece of traditional Chinese medicine Xiaozao granule on the treatment of serum interleukin （IL） -2，IL-4 and interferon （IFN）-γ in severe acne 　　LIN Wuquan 　　Longgang Hospital of Traditional Chinese Medicine，Shenzhen 518100，China 　　[Abstract] Objective To evaluate the effect of traditional Chinese medicine Xiaozao granule on the treatment of serum interleukin （IL）-2，IL-4 and interferon （IFN）-γ in severe acne. Methods 60 patients with severe acne treated from December 2013 to December 2015 were selected as the subjects of this study.According to the random number table method.The patients were divided into control group and observation group with 30 cases in each.Patients in control group were treated with Conventional Western Medicine，and patients in observation group were treated with Western medicine therapy combined with Xiaocuo granule.2 months for 1 courses，the 2 groups were 2 consecutive treatment courses.The levels of IL-2，IL-4，IL-4 and IL-4 in the two groups were measured before and after treatment.The levels of IL-2，IL-4 and IL-IFN-γ levels were observed and compared. Results In the treatment of the total effective rate，the observation group and the control group were 96.67% and 83.33%，compared between the groups，the difference was statistically significant（P0.05）.After treatment，the levels of IL-4 in serum were significantly decreased （P 　　[Key words] Severe acne；Inter