滋水清肝饮对围绝经期抑郁症患者临床疗效及对血清孤啡肽和5―羟色胺影响分析.docVIP

滋水清肝饮对围绝经期抑郁症患者临床疗效及对血清孤啡肽和5―羟色胺影响分析 　　【摘要】 目的：探究滋水清肝饮对围绝经期抑郁症患者的临床疗效及对血清孤啡肽（OFQ）和5-羟色胺（5-HT）的影响分析。方法：选取2014年1月-2015年1月本院收治的围绝经期抑郁症患者60例，随机分为滋水清肝饮组和激素替代组各30例，滋水清肝饮组给予滋水清肝饮治疗，2次/d，15 d为1个疗程，连服3个月；激素替代组患者均服用倍美力0.625 mg/d，服药第16天加服安宫黄体酮10 mg/d，共5 d，用药3个月。于治疗前后两组均进行HAMD评分，分别检测血清OFQ和5-HT的水平。结果：滋水清肝饮组总有效率为80.00%，高于激素替代组的66.67%，两组比较差异有统计学意义（P0.05）。滋水清肝饮组治疗1、2、3个月后的OFQ水平分别为（19.84±5.14）、（14.97±4.13）ng/L和（12.52±3.84）ng/L，均低于对照组的（23.71±5.86）、（18.86±4.28）ng/L和（15.69±3.67）ng/L，组间比较差异均有统计学意义（P0.05）；滋水清肝饮组治疗1、2、3个月后的5-HT水平分别为（1.19±0.42）、（1.28±0.34）μg/L和（1.46±0.38）μg/L，均高于对照组的（0.98±0.36）、（1.14±0.41）μg/L和（1.24±0.42）μg/L，组间比较差异均有统计学意义（P0.05）。结论：滋水清肝饮治疗围绝经期抑郁症，可以降低患者血清OFQ的水平，提高5-HT的水平，显著改善围绝经期抑郁症患者的抑郁状态，疗效确切，值得应用于临床。 　　【关键词】 滋水清肝饮； 围绝经期抑郁症； OFQ； 5-羟色胺 　　Effects of Zishuiqinggan Decoction in Treatments of Patients with Perimenopausal Depression and It’s Impact of Orphanin FQ and 5-hydroxytryptamine/TANG Li-bin，ZHANG Zhi-fu.//Medical Innovation of China，2016，13（20）：110-112 　　【Abstract】 Objective：To discuss effects of Zishuiqinggan Decoction in treatment of patients with perimenopausal depression and it’s impact of orphanin FQ and 5-hydroxytryptamine.Method：A total of 60 patients with perimenopausal depression from January 2014 to January 2015 in our hospital were randomly selected and divided into 30 patients of them treated with Zishuiqinggan Decoction were taken as Zishuiqinggan decoction group，while the other 30 patients treated with Premarin and Medroxyprogesterone acetate were taken as hormone replacement therapy group.Scored HAMD for patients before and after treatments，and respectively detected the levels of OFQ and 5-HT.Result：The total effective rate of the Zishuiqinggan Decoction group was 80.00% while that in the hormone replacement therapy group was 66.67%，the differences between two groups had statistical significance（P 　　【Key words】 Zishuiqinggan Decoction； Perimenopausal depression； Orphanin FQ； 5-hydroxytryptamine 　　First-author’s address：Longhua New District Peopl