电子线放射联合局部注射5―氟尿嘧啶与曲安奈德治疗瘢痕疙瘩疗效分析.docVIP

电子线放射联合局部注射5―氟尿嘧啶与曲安奈德治疗瘢痕疙瘩疗效分析 　　[摘要]目的：探讨电子线放射联合局部注射5-氟尿嘧啶和曲安奈德治疗瘢痕疙瘩的疗效。方法：选取瘢痕疙瘩患者41例，病灶51处，平均病史4.5年，平均治疗时间为6个月。根据是否使用电子线放射分为对照组和实验组，其中对照组21例，采用患处局部注射5-氟尿嘧啶和曲安奈德混悬液（比例2：1），每3周1次；实验组20例，除在患处局部注射5-氟尿嘧啶和曲安奈德混悬液外辅以电子线放射治疗，6个月后观察效果。结果：治疗6个月后，实验组总有效率95.0%，对照组为85.7%，两组疗效比较有显著性差异（P0.05）。结论：5-氟尿嘧啶和曲安奈德混悬液辅以电子线放射治疗瘢痕疙瘩疗效显著。 　　[关键词]瘢痕；放射；治疗 　　[中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455（2015）10-0057-03 　　Efficacy analysis of electron irradiation combined with local injection of 　　5-fluorouracil and triamcinolone acetonide for the treatment of keloids 　　CHU Guo-hua 　　（Burns and Plastic Surgery，Cangzhou Hospital of Integrated Traditional and Western Medicine， Cangzhou 061000，Hebei，China） 　　Abstract： Objective To investigate the curative effect by the way of electron irradiation combined with 5-fluorouracil and triamcinolone acetonide. Methods We chose 41 patients with 51 keloid lesion， the average age of onset was 4.5 years，the average treatment time was six months.We divided the patients into control group and experimental group according to whether or not to use the electron irradiation.There were 21 patients in the control group who were injected 5-fluorouracil and triamcinolone acetonide suspension （ratio 2：1） three times a week.There were 20 patients in the experimental group， except injecting suspension，we use the radiation therapy for them.The result would be observed after six months. Results After 6 months，the total effectiveness of experimental group was 95.0%，and control group was 85.7%.The curative effect of two groups was more significant difference （P0.05）. Conclusion It is significantly effective for electron irradiation combined with local injection of 5-fluorouracil and triamcinolone acetonide in the treatment of keloids. 　　Key words：keloid；radiation；treatment 　　瘢痕疙瘩为隆出正常皮肤，形状不规则、红色或粉色、质硬、增厚肥大的良性肿块。它是在皮肤损伤愈合过程中，胶原合成代谢机能紊乱，持续处于亢进状态，以致胶原纤维过度增殖而成。作为皮肤科和整形科常见疾病，瘢痕疙瘩给患者的身心健康造成巨大损害，严重时可出现疼痛、瘙痒，甚至影响患者的躯体关节活动，最终导致患者生活质量的受损和躯体功能的减弱。 　　瘢痕疙瘩的治疗方法较多，包括手术、放射线、冷冻、