肝癌手术切除术前外周血中CD4CD8值及总胆汁酸量与患者预后相关性分析.docVIP

肝癌手术切除术前外周血中CD4CD8值及总胆汁酸量与患者预后相关性分析 　　[摘要] 目的 探?术前外周血中CD4+/CD8+值及血清总胆汁酸的量在预测患者预后中的价值。方法 方便选择2012年1月―2014年6月住院接受肝癌部分切除的77例患者作为研究对象，测定术前患者外周血中CD4+/CD8+值及血清中总胆汁酸（TBA）含量，手术后对患者进行随访，并对患者性别、年龄、术前CD4+/CD8+值、TBA值及肿瘤情况，术后远处转移，复发情况进行系统性分析。结果 术前低CD4+/CD8+值组患者术后第1年复发率58.62%，第3年复发率89.66%均显著高于高CD4+/CD8+值组的8.33%和20.83%（P45 μmol/L）患者的预后较差，复发率较高。 　　[关键词] 肝癌；CD4+/CD8+值；总胆汁酸；相关性 　　[中图分类号] R735 [文献标识码] A [文章编号] 1674-0742（2017）08（c）-0012-03 　　Analyis of Correlation between the CD4+/CD8+ Values in the Peripheral Blood before the Liver Cancer Surgery and Total Bile Acid Amount and Prognosis of Patients 　　TIAN Ming-liang 　　Department of Oncology Surgery， First Affiliated Hospital of Baotou Medical College， Baotou， Inner Mongolia， 014010 　　[Abstract] Objective To study the value of CD4+/CD8+ values in the peripheral blood before surgery and total bile acid amount in predicint the value of prognosis. Methods 77 cases of patients with partial hepatectomy for liver cancer before surgery in our hospital from January 2012 to June 2014 were convenient selected as the research objects and the CD4+/CD8+ value and serum TBA content of patients before surgery were measured and the patients were followed up after surgery and the gender， age， postopertive CD4+/CD8+ values and TBA value and tumor situation of patients， recurrence were systematically analyzed. Results The 1-year recurrence rate and 3-year recurrence rate in the low CD4+/CD8+ value group before surgery was obviously higher than that in the high CD4+/CD8+ value group，（58.62%， 89.66% vs 8.33%， 20.83%）（P 45μmol/L） before the liver cancer incision surgery is worse and the recurrence rate is high. 　　[Key words] Liver cancer； CD4+/CD8+ value； Total bile acid； Correlation 　　机体的免疫状态与肝癌的发病及术后复发存在密切联系，患者CD4+/CD8+的比值可通过机体免疫状态来间接预测肝癌的复发。肝脏是合成和摄取胆汁酸的唯一场所，所以总胆汁酸水平可作为肝实质损伤的敏感指标[1]。该研究回顾性分析2012年1月―2014年6月于医院就诊的77例肝癌患者的临床资料，探讨术前外周血中CD4+/CD8+值及血清总胆汁酸的量在预测患者预后中的价值，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　方便选择住院接受肝癌部分切除的77例患者作为研究对象，所有病例均经过CT检查或核磁共振（MRI）、甲