评价甲氨蝶呤联合米非司酮连续用药保守治疗异位妊娠疗效及安全性.docVIP

评价甲氨蝶呤联合米非司酮连续用药保守治疗异位妊娠疗效及安全性 　　[摘要] 目的 分析针对异位妊娠患者以甲氨蝶呤、米非司酮联合用药治疗的临床效果，并观察该治疗方案的安全性。方法 便利选择2012年6月―2017年6月间该院妇科病房接收的患异位妊娠的120例患者，随机分成2组：参考组共60例，确诊后单以甲氨蝶呤用药；联合组共60例，确诊后以甲氨蝶呤、米非司酮联合用药治疗。疗程结束后对2组患者治疗完毕后的疗效进行评估，且观察患者的包块大小、血β-HCG水平变化与用药后的不良反应发生情况。 结果 联合组患者疗程结束后的总有效率为（93.33%），较参考组的（73.33%）显著更高（P0.05）；联合组患者治疗后的包块直径（14.62±3.37）mm与治疗前（37.68±9.69）mm、参考组（20.86±5.74）mm相比显著更短，治疗后血β-HCG水平（1166.74±108.57）IU/L与治疗前（2059.48±199.77）IU/L、参考组（1423.61±105.91）IU/L相比显著更低（P0.05）。2组用药后的不良反应均较轻。结论 异位妊娠患者以甲氨蝶呤、米非司酮联合用药治疗可获良好的疗效，安全性较高，值得借鉴。 　　[关键词] 米非司酮；甲氨蝶呤；异位妊娠；疗效 　　[中图分类号] R714 [文献标识码] A [文章编号] 1674-0742（2017）10（b）-0134-03 　　[Abstract] Objective This paper tries to analyze the clinical effect of methotrexate combined with mifepristone in the treatment of patients with ectopic pregnancy and to observe the safety of treatment. Methods 120 cases of patients with ectopic pregnancy received in this hospital from June 2012 to June 2017 were convenient selected and were randomly divided into two groups： the control group of 60 cases was given the methotrexate only after the diagnosis， while the 50 cases of the combined group were treated with methotrexate combined with mifepristone. Then， the clinical effects of two groups of patients after the course of treatment were evaluated， and the size of the masses， the changes of blood β-HCG levels and the adverse reactions after the drug were observed. Results The total effective rate at the end of the course in the combined group was 93.33%， significantly higher than that in the control group of 73.33%（P0.05）； In the combined group， the diameter of the masses after the treatment was （14.62±3.37）mm， significantly shorter than that before the treatment of （37.68±9.69）mm and the control group of （20.86±5.74）mm. After the treatment， the level of blood β-HCG was （1166.74±108.57）IU/L， significantly lower than that before treatment of （2059.48±199.77）IU/L and control group of （1423.61±105.91）IU/L （P0.05）. The adverse reactions of the two groups were mild