邦亭在颅脑创伤治疗中应用.docVIP

邦亭在颅脑创伤治疗中应用 　　[摘要] 目的：研究邦亭在治疗颅脑创伤中的止血作用与安全性。方法：将60例颅脑创伤的患者随机分为邦亭组（30例）和对照组（30例），邦亭组给予邦亭1 U，2次/d，静滴2～3 d，对照组给予氨甲环酸1 g，2次/d，静滴2～3 d，观察出血情况及不良反应。结果：邦亭组止血效果与对照组比较，差异无统计学意义（P＞0.05）；邦亭组不良反应低于对照组（P0.05）。结论：邦亭在治疗颅脑创伤中止血效果良好，安全性好。 　　[关键词] 邦亭；颅脑创伤；氨甲环酸 　　[中图分类号] R473.6[文献标识码]B [文章编号]1673-7210（2010）10（a）-066－０2 　　 　　Clinical application of Hemocoagulase for Injection in the treatment of craniocerebral trauma 　　ZHU Chunran, LI Wei, ZHANG Yong 　　(Department of Neurosurgery, Combination of Traditional Chinese Medicine and Western Medicine Hospital, Jiangsu Province, Nanjing 210028, China) 　　[Abstract] Objective: To study the hemostatic effect and safety of Hemocoagulase for Injection in the treatment of craniocerebral trauma. Methods: 60 cases were randomly divided into treatment group (30 cases) and control group (30 cases), and they were treated with Hemocoagulase for Injection (1 U/time, 2 times/d, 2-3 d, intravenous drip) and Tranexamic Acid (1 g/time, 2 times/d, 2-3 d, intravenous drip) respectively. The bleeding status and adverse reaction were observed. Results: The two groups showed no significant difference in hemostatic effect (P＞0.05), but the incidence rate of adverse reaction was lower in treatment group than that of control group (P0.05). Conclusion: It is an effective drug in the treatment of bleeding for patients with craniocerebral trauma, with more safety. 　　[Key words] Hemocoagulase for Injection; Craniocerebral trauma; Tranexamic Acid 　　 　　轻型颅脑损伤患者表现为意识清楚、能正确回答问题、恶心呕吐等；中型颅脑损伤患者出现精神淡漠、不愿说话、嗜睡或烦躁不安、剧烈头痛、头昏，恶心呕吐等症状；重型颅脑损伤患者则表现为昏迷、躁动不安或完全不动、剧烈呕吐、偏瘫或瘫痪、呼吸困难、甚至出现大小便失禁等症状[1]。临床对于患者意识、瞳孔变化及恶心呕吐等症状的观察极为重要，往往是选择复查头颅CT或手术的时机。本文中笔者选择2008年1月～2010年6月我科60例颅脑创伤患者，均分为两组，分别给予注射用白眉蛇毒血凝酶（商品名：邦亭，以下称邦亭）和氨甲环酸治疗，现将治疗效果报道如下： 　　1 资料与方法 　　1.1 一般资料 　　本组共60例患者，将其随机分为邦亭组和对照组，各30例。邦亭组30例中，男12例，女18例；年龄19～68岁；蛛网膜下腔出血11例，硬膜外血肿8例，硬膜下出血6例，合并脑挫裂伤5例。对照组30例中，男11例，女19例；年龄21～67岁；蛛网膜下腔出血10例，硬膜外血肿9例，硬膜下出血7例，合并脑挫裂伤4例。所有病例肝功能、凝血功能、血小板均正常，无出血倾向或血栓疾病史。两组年龄、性别、疾病种类、手术创伤度等方面差异无统计学意义（P＞0.05），具