长春西汀与弥可保联合用药治疗糖尿病周围神经病变临床观察.docVIP

长春西汀与弥可保联合用药治疗糖尿病周围神经病变临床观察 　　【摘要】目的观察长春西汀与弥可保联合用药治疗糖尿病周围神经病变的疗效。方法将140例2 型糖尿病合并周围神经病变患者随机分成两组，对照组70 例，试验组70 例。对照组给予弥可保500 μg，肌肉注射，每日1次；试验组给予长春西汀20 mg溶于250 ml 0?9%氯化钠溶液中静滴，每日1次及弥可保500μg 肌注，每日1次。两组疗程均为14 d，观察其对神经传导速度的影响。结果治疗14 d 后，患者主观症状和体征有较明显改善。试验组总有效率为80?0％，对照组总有效率为61?0%。两组疗效比较，差异有统计学意义（P＜0?05）。神经传导速度两组治疗后比较，差别有统计学意义（P＜0?05）。结论长春西汀与弥可保治疗糖尿病周围神经病变有显著疗效，联合用药明显优于单用神经营养药物。【关键词】长春西汀 弥可保 糖尿病周围神经病变 　　Effect of Mecobalamine and Vinpocetine in treatment of diabetic peripheral neuropathyLI Yan. The First Hospital of Xinxiang Medical University, Xinxiang 453100,China【Abstract】ObjectiveTo observe the effect of Mecobalamine and Vinpocetine in the treatment of diabetic peripheral neuropathy.Methods140 Patients with diabetic peripheral neuropathy were divided randomly into two groups; the control group (70 cases) and the treatment group (70 cases). The patients of the treatment group were given with Vinpocetine 20 mg dissolved in 0?9% normal saline solution 250 ml once a day intravenously, and given mecobalamine 500 μg once a day intramuscular; and in the control group were only given with mecobalamine 500μg once a day intramuscular. Nerve conduction velocity in two groups of patients was observed after 14 days treatment.ResultsAfter treatment for 14 days, the subjective symptoms and signs were significantly improved with a total effective rate of 80?0% in the treatment group versus 61?0% in the control group. Compared with the control group, the total effective rates of treatment group was significantly higher (P0?05) and nerve conduction velocity improved significantly(P0?05).ConclusionMecobalamine and Vinpocetine in treatment of Diabatic Peripheral Neuropathy is very effective, the combination medica- tion is superior obviously to the nerve nutrition medicine only.【Key words】Mecobalamine;Vinpocetine;Diabetic peripheral neuropathy糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)是糖尿病常见的慢性并发症之一, 病变可累及全身神经系统，按症状出现部位可分为：颅神经型、(肢体)近端型、(肢体)远端型与躯干型障碍。临床以对称性肢体疼痛、感觉减退、麻木为主要特征,可使患者生活质量下降,