阿托伐他汀治疗对急性冠脉综合征患者血清sCD40sCD40L和MMP―9影响.docVIP

阿托伐他汀治疗对急性冠脉综合征患者血清sCD40sCD40L和MMP―9影响 　　摘要：目的 探讨急性冠脉综合征患者血清血清sCD40、sCD40L和MMP-9的变化，以及阿托伐他汀治疗对其的影响，初步探讨阿托伐他汀对急性冠脉综合征的预防与治疗机制。方法 将120例急性冠脉综合征患者随机分为A组（n=60）和B组（n=60），A组常规治疗，B组在常规治疗基础上加服阿托伐他汀，在治疗前后分别测定每组患者血清sCD40、sCD40L和MMP-9水平。结果 急性冠脉综合征血清sCD40、sCD40L和MMP-9水平较对照组显著升高（P0.05）。结论 血清sCD40、sCD40L和MMP-9可能与急性冠脉综合征发生发展有关，阿托伐他汀能显著降低急性冠脉综合征患者sCD40、sCD40L和MMP-9水平，治疗急性冠脉综合征的机制可能与调节血清sCD40、sCD40L和MMP-9水平有关。 　　关键词：阿托伐他汀；急性冠脉综合征；sCD40L；sCD40L；MMP-9 　　Effect of atorvastatin on the levels of sCD40L，sCD40L and MMP-9 in patients with acute coronary syndrome 　　CHEN Fang 　　（Department of cardiology，Yiyang Central Hospital，Yiyang 413000， Hunan，China） 　　Abstract：Objective To explore the change of atorvastatin on acute coronary syndrome patients and the impacts on the expressions of sCD40L，sCD40L and MMP-9， to study the mechanism for its prevention and treatment of acute coronary syndrome. Methods The clinica1 observation of using randomized contro1ed method，120 cases of acute coronary syndrome patients were divided into A and B group. The group A were treated only with conventional therapy， The group B was given atorvastatin besides conventional therapy. And the concentrations of sCD40L，sCD40L and MMP-9 in serum were detected before and after therapy. Results The level of serum sCD40L、sCD40L and MMP-9 in ACS patients were significant increase as to control group（all P0.05）. Conclusion There may be a relevant between serum sCD40L， sCD40L，MMP-9 and the incidence of acute coronary syndrome， atorvastatin can significantly reduce the levels of sCD40L，sCD40L，MMP-9 in acute coronary syndrome patients， the mechanism of atorvastatin treat acute coronary syndrome may be related to regulating the serum level of sCD40L，sCD40L and MMP-9. 　　Key words：Atorvastatin；Acute coronary syndrome；sCD40L；sCD40L；MMP-9 　　急性冠脉综合征（Acute coronary syndrome，ACS） 是急性严重的心肌缺血性心脏猝死的一种临床综合征， 以冠状动脉粥样硬化斑块破裂或侵蚀，继发完全或不完全闭塞性血栓形成为病理基础。近年来，越来越多的证据证明，动脉粥样硬化斑块破裂的纤维帽局部有大量活化的巨噬细胞、泡沫细胞浸润，炎症反应加剧了斑块的不稳定性，炎症反应过程在ACS的发病机制中起重要作用[1]。研究