阿尔茨海默病患者血尿酸水平变化研究.docVIP

阿尔茨海默病患者血尿酸水平变化研究 　　摘 要：目的 分析阿尔茨海默病患者血尿酸水平变化，探讨血尿酸在AD患者发病机制的作用。方法 收集2013年1月～2017年4月我科收治的AD患者94例为AD组，同时收集体检中心同年龄段、性别比例构成相似的健康体检人群127例为健康对照组。对两组尿酸水平进行检测分析。结果 AD组血尿酸水平低于健康对照组，差异有统计学意义（P0.01）；健康对照组女性血尿酸水平低于男性，差异有统计学意义（P0.01）；AD组女性血尿酸水平低于男性，差异有统计学意义（P0.05）。结论 血尿酸在AD发病机制中起重要作用，与AD的发生发展密切相关，血尿酸可能为AD的保护因素之一。 　　关键词：阿尔茨海默病；血尿酸；氧化应激；发病机制；保护因素 　　中图分类号：R749.16 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.02.033 　　文章编号：1006-1959（2018）02-0096-03 　　Abstract：Objective To analyze the changes of serum uric acid in patients with Alzheimers disease and to explore the role of serum uric acid in the pathogenesis of AD.Methods From January 2013 to April 2017，94 patients with AD in our department were enrolled as AD group，and 127 healthy people with similar sex ratio in the same age group were collected as healthy control group.The two groups of uric acid levels were analyzed. Results The level of serum uric acid in AD group was lower than that in healthy control group，the difference was statistically significant（P0.01）；The level of serum uric acid in female healthy control group was lower than that in male group，the difference was statistically significant（P0.01）.The level of serum uric acid in female AD group was lower than that in male group，the difference was statistically significant（P0.05）.Conclusion Serum uric acid plays an important role in the pathogenesis of AD and is closely related to the occurrence and development of AD.Serum uric acid may be one of the protective factors of AD. 　　Key words：Alzheimers disease；Blood uric acid；Oxidative stress；Pathogenesis；Protection factors 　　阿??茨海默病（alzheimers disease，AD）是老年人常见的神经系统变性疾病，也是老年人痴呆常见原因之一，发病率随年龄增长逐渐增高。AD常见病理特征为老年斑、神经元纤维缠结、海马椎体细胞颗粒空泡变性及神经元缺失。目前AD的病因及其病理学变化过程尚未完全明确，这导致人们对该疾病认识十分局限。研究表明，氧化应激可能在AD的发病机制及病程进展中起重要作用，AD的起病可能与血浆中一些抗氧化剂，如血尿酸含量减少有一定关系[1]。血尿酸是嘌呤碱基代谢的产物，是人体中重要的抗氧化剂之一，能通过清除血液中的自由基等方式抗氧化。目前AD患者血尿酸水平与正常人相比是否存在差异尚未得到统一认识，研究认为，AD患者血尿酸水平低于正常人[2]，但同样有研究认为血尿酸水平与AD的发生发展无关[3-4]，血尿酸在AD的起病经过及病程进展中所起作用也尚未明确。故本文旨在研究AD患者血尿酸水平变化，为AD的防治及诊疗提