黄芩苦参合剂雾化吸入预防化疗后下呼吸道感染并发侵袭性真菌感染临床研究.docVIP

黄芩苦参合剂雾化吸入预防化疗后下呼吸道感染并发侵袭性真菌感染临床研究 　　[摘要] 目的 探讨黄芩苦参合剂雾化吸入对化疗后下呼吸道院内感染患者并发侵袭性肺部真菌感染的预防作用。方法 选择60例肿瘤化疗后下呼吸道院内感染老年患者，随机分为对照组及治疗组，每组30例，所有患者均依据药敏结果抗感染治疗，治疗组患者另给予黄芩苦参合剂雾化吸入每日2次，2周后比较两组患者临床治疗效果，观察两组肺部真菌感染发生率及发生时间，比较两组患者治疗前后血气分析情况。 结果 治疗组临床有效率86.67%，对照组临床有效率70.00%，治疗组临床有效率高于对照组；治疗组肺部真菌感染率6.67%，对照组肺部真菌感染率23.33%，治疗组真菌感染率低于对照组；治疗组真菌感染时间（11.58±1.3）d，对照组真菌感染时间（9.41±1.10）d，治疗组真菌感染时间迟于对照组；两组患者治疗前血气分析pH、SaO2、PaCO2、PaO2水平无显著差异，治疗2周后治疗组pH、SaO2、PaO2水平高于对照组，PaCO2水平低于对照组。 结论 黄芩苦参合剂雾化吸入能够改善化疗后下呼吸道院感老年患者的临床疗效，改善呼吸功能，预防继发侵袭性肺部真菌感染，具有较好的临床效果。 　　[关键词] 真菌感染；呼吸道感染；黄芩苦参合剂；院内感染；老年人 　　[中图分类号] R272 [文献标识码] B [文章编号] 1673-9701（2015）12-0102-04 　　Clinical study of atomization inhalation with mixture of baikal skullcap root and lightyellow sophora root for proventing invasive fungal infections on lower respiratory tract infection after chemotherapy 　　FANG Qun1 GAO Xiangfu2 MAO Xianghong3 LOU Liming4 ZHANG Lingling1 CHEN Fulan4 LIN Min5 CHEN Xiaoming6 　　1.Department of Hospital Infection Branch， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China；2.Department of Traditional Chinese Medicine， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China；3.Depatrment of Clinical Laboratory， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China；4.Department of Respiration， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China；5.Department of Radiology， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China；6.Department of Equipment， the Third Affiliated Hospital of Zhejiang University of TCM， Hangzhou 310005，China 　　[Abstratct] Objective To investigate the preventive effect of atomization inhalation with mixture of baikal skullcap root and light yellow sophora root for proventing invasive fungal infection on lower respiratory tract infection after chemotherapy. Methods A total of 60 cases of patients with lower respiratory tract infections after chemotherapy wer