高迁移率族蛋白B1和增殖细胞核抗原在宫颈癌组织中表达及其相关因素分析.docVIP

高迁移率族蛋白B1和增殖细胞核抗原在宫颈癌组织中表达及其相关因素分析 　　[摘要] 目的 探讨高迁移率族蛋白B1（HMGB1）和增殖细胞核抗原（PCNA）在宫颈癌组织中的表达及其相关因素。 方法 选取2008年9月～2014年10月我院收治的60例宫颈癌患者作为研究对象，手术留取宫颈癌组织标本60份（宫颈癌组）、癌旁组织标本60份（癌旁组）、正常组织标本60份（正常组），采用免疫组织化学法检测三组HMGB1和PCNA的表达，并分析两指标与临床病理特征的关系。 结果 宫颈癌组、癌旁组和正常组的HMGB1阳性表达率分别为96.7%、23.3%和6.7%，差异有统计学意义（P0.05）；宫颈癌组、癌旁组和正常组的PCNA阳性表达率分别为91.7%、66.7%和43.3%，差异有统计学意义（P0.05）。HMGB1的表达与TNM分期、淋巴结转移及肿瘤分化程度相关，PCNA的表达与TNM分期、淋巴结转移、浸润深度及肿瘤分化程度相关，差异有统计学意义（P0.05）。 结论 宫颈癌患者的宫颈癌组织中，HMGB1及PCNA表达水平均显著增高，两项指标对宫颈癌的预后评估具有重要意义。 　　[关键词] 宫颈癌；高迁移率族蛋白B1；增殖细胞核抗原 　　[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0050-03 　　Expression of high mobility group protein B1 and proliferating cell nuclear antigen in cervical cancer tissues and and the analysis of related factors 　　DING Wen-qing 　　Department of Gynaecology，Maternal and Child Health Hospital of Longgang District in Shenzhen City，Shenzhen 518172，China 　　[Abstract] Objective To investigate the expression of high mobility group protein B1 （HMGB1） and proliferating cell nuclear antigen （PCNA） in cervical cancer tissues and its related factors. Methods 60 cases of cervical cancer treated in our hospital from September 2008 to October 2014 were selected as the research objects，and 60 cases of cervical cancer tissues（cervical cancer group），60 cases of adjacent tissue samples （adjacent group） and 60 cases of normal tissue samples （normal group） were collected by surgery.The expression of HMGB1and PCNA among three groups were detected by immunohistochemistry，and the relationship between the two indexes and clinical pathological features were analyzed. Results The positive expression rates of HMGB1 in cervical cancer group，adjacent group and normal group was respectively 96.7%，23.3% and 6.7%，the difference was statistically significant（P0.05）.The positive expression rates of PCNA in cervical cancer group，adjacent group and normal group was respectively 91.7%， 66.7% and 43.3%，the difference was statistically significant（P0.05）. The expression of HMGB1 was