银屑病患者血小板参数C反应蛋白和血脂及载脂蛋白检测分析.docVIP

银屑病患者血小板参数C反应蛋白和血脂及载脂蛋白检测分析 　　[摘要] 目的 探讨银屑病患者血小板参数、C反应蛋白(CRP)与血脂及载脂蛋白水平变化在银屑病发病中的作用及临床应用价值。方法 对96例寻常型银屑病患者血小板参数、CRP以及血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDH-C)和载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及脂蛋白a(LPa)进行检测,并与正常对照组进行综合对比分析。结果 银屑病组与对照组比较:银屑病组血小板压积(PCT)、平均血小板体积(MPV)和血小板分布宽度(PDW)明显升高(P0.05)。进行期银屑病组CRP浓度与对照组比较差异有高度显著性(P0.05)。结论 银屑病患者血小板参数、CRP与血脂及载脂蛋白水平均有明显变化,联合监测对于判断病情转归和指导临床治疗具有重要意义。 　　[关键词] 银屑病;血小板参数;C反应蛋白;血脂;载脂蛋白 　　[中图分类号] R758.63[文献标识码] A[文章编号] 1673-9701(2010)10-03-02 　　 　　Detection and Analysis of Platelet Parameter, C-reactive Protein and Blood Lipids and Apolipoproteins in Psoriasis 　　MA XiuhuaWANG Yuliang 　　Clinical Laboratory,Shandong Province Coal Linyi Hot Spring Sanatorium,Linyi 276032,China 　　 　　[Abstract] Objective To explore the effects of platelet parameter,C-reactive protein(CRP),blood lipids and apolipoprotein in the pathogenesis of psoriasis and clinical application. Methods We detected blood platelet parameter,CRP,serum total cholesterol(TC), triglyceride(TG),high density lipoprotein cholesterol(HDL-c),low density lipoprotein cholesterol(LDH-c) and apolipoprotein A1(ApoA1),apolipoprotein B(ApoB) and lipoprotein a(LPa) and the contrastive analysis was made with the normal control group. Results The blood platelet pressure accumulation(PCT),the average blood platelet volume(MPV) and the blood platelet distribution width(PDW) were obviously elevated in the psoriasis group compared with the control group(P0.05). Conclusion The blood platelet parameter,the CRP and the blood lipids and apolipoprotein in psoriasis show obvious changes,and their joint monitoring is of very importance for judging disease prognosis and guidance for its clinical therapy. 　　[Key words] Psoriasis;Blood platelet parameter;C-reactive protein;Blood fats;Apolipoprotein 　　银屑病是一种常见的慢性复发性炎症性皮肤病,典型皮损为鳞屑性红斑,其确切病因尚未清楚。目前认为,银屑病是遗传因素因素与环境因素等多种因素相互作用的多基因遗传病,通过免疫介导的共同通路最后引起角质形成细胞发生增殖[1]。有研究报道,银屑病患者血液黏度升高[2],存在内源性甘油三酯水平及其运转升高,易伴发高脂血症、动脉硬化等疾病,在银屑病表皮中脂质代谢不正常等[3]。本文对银屑病患者血小板参数、C反应蛋