柴平汤加减治疗功能性消化不良（肝郁气滞挟湿证）的临床观察-中医内科学(脾胃病)专业论文.docxVIP

成都中医药大学二 成都中医药大学二 0 一五届硕士研究生学位论文 万方数据 万方数据 中文摘要 目的：观察和评价柴平汤加减治疗功能性消化不良（肝郁气滞挟湿证）的临床疗 效及安全性。 方法：按就诊先后顺序将符合纳入标准的 60 例功能性消化不良（肝郁气滞挟湿 证）患者随机分成两组。治疗组 30 例，给予中药柴平汤加减治疗；对照组 30 例，给予多潘立酮片和奥美拉唑肠溶胶囊治疗。两组均服药 4 周，在治疗期间两 组均不允许服用其它药物，劳逸适度，并忌饮浓茶、咖啡，禁食辛辣刺激性食物、 冷硬、油腻之物等。主要观察项目为临床综合疗效、中医症状积分、安全性等指 标。并用 SPSS19.0 统计软件对相关数据进行分析，得出结论。 结果：（1）治疗组总有效率为89.65%，对照组为79.31%，两组的临床疗效差异有 统计学意义（P0.05），治疗组优于对照组；（2）组内比较：两组治疗前后中医 症状积分比较均有统计学意义（P0.05）；（3）组间比较：两组治疗后中医症状 总积分差异有统计学意义（P0.05），单项中医症状积分比较在嗳气泛酸、失眠 多梦、排便不爽上无统计学差异（P0.05），其余各症状中医症状积分改善程度 治疗组均优于对照组（P0.05），尤其在改善胃脘部胀满不适、纳差食少这两项 症状上治疗组效果更显著（P0.01）；（4）治疗结束后随访2个月，治疗组复发 率为7.69%，对照组复发率为26.09%，两组比较，差异有统计学意义（P0.05）； （5）治疗组和对照组均未见不良反应。 结论：“柴平汤”具有疏肝理气，燥湿和胃的作用，对治疗肝郁气滞挟湿型 FD 临 床疗效显著，可减少 FD 的复发，作用安全，值得进一步推广和研究。 关键词：功能性消化不良；柴平汤；肝郁气滞挟湿证；临床观察 1 Abstract Objective: To observe and evaluate the clinical efficacy and safety of modified Chaiping decoction in treatment of functional dyspepsia (stagnation of liver Qi with dampness syndrome). Methods: According to the sequence for the treatment,60 patients met the inclusion criteria of functional dyspepsia (stagnation of liver Qi with dampness syndrome) were randomly divided into two groups. 30 patients of the treatment group were treated with traditional chinese medicine Chaiping decoction;30 cases of control group were given Domperidone tablets and Omeprazole Enteric-coated Capsules.The two groups were both 4 weeks of therapy,and during the treatment period were not allowed to take other drugs, worked and rest appropriately, and avoided drinking tea, coffee and fasting spicy excitant food, chilled things and so on. The main observation items were the comprehensive clinical efficacy, TCM symptom score, safety indices etc.With SPSS 19.0 statistical software to analyze the related data, draw conclusions. Results: （ 1 ） The total effective rate of treatment group was 89.65% and that of control group was 79.31%．There was statistical significance between the two groups of clinical curative effect difference(P0.05), the treatm