柴芍六君子汤辅助化疗治疗肝郁脾虚型中晚期胰腺癌临床的研究.docVIP

柴芍六君子汤辅助化疗治疗肝郁脾虚型中晚期胰腺癌临床的研究 　　摘要：目的 ?^察柴芍六君子汤辅助化疗治疗肝郁脾虚型中晚期胰腺癌临床疗效。方法 采用随机数字表法将60例患者分为治疗组和对照组各30例。2组均予营养支持，维持电解质平衡，三级止痛及抗感染等基础治疗。治疗组予卡培他滨片，每次1250 mg/m2，每日2次，餐后30 min口服。连续治疗2周、停药1周为1个化疗周期，共治疗2个周期。治疗组在对照组基础上予柴芍六君子汤，每日1剂，早晚分服，共治疗6周。2组均随访4周。观察2组患者实体瘤疗效、中医症状疗效及血清消化道癌相关抗原（CA19-9）疗效。观察治疗前后体力状况评分，监测化疗毒副反应。结果 对照组失访1例，共59例患者完成观察。治疗组肿瘤稳定率为76.7%（23/30），对照组为65.5%（19/29），2组比较差异无统计学意义（P0.05）；治疗组中医症状疗效总有效率为90%（27/30），对照组为69%（20/29），2组比较差异有统计学意义（P0.05）；治疗组血清CA19-9疗效优于对照组（P0.05）。2组发生不同程度化疗毒副反应（P0.05）。结论 柴芍六君子汤辅助化疗治疗中晚期胰腺癌可改善患者主要临床症状，降低血清CA19-9水平，减轻化疗的毒副反应。 　　关键词：胰腺癌；柴芍六君子汤；卡培他滨 　　DOI：10.3969/j.issn.1005-5304.2018.02.006 　　中图分类号：R273.59 文献标识码：A 文章编号：1005-5304（2018）02-0026-04 　　Clinical Study on Chaishao Liujunzi Decoction Combined with Chemotherapy 　　in Treating Advanced Pancreatic Cancer 　　LIU Hua1， WU Jing2， SUN Tong-lin2 　　1. The First Affiliated Hospital of Hunan University of Chinese Medicine， Changsha 410007， China； 　　2. Hunan University of Chinese Medicine， Changsha 410007， China 　　Abstract： Objective To observe and analyze the clinical efficacy of Chaishao Liujunzi Decoction combined with chemotherapy in the treatment of advanced pancreatic cancer with liver depression and spleen deficiency. Methods Totally 60 cases of advanced pancreatic cancer patients were divided into treatment group and control group according to random number table method， with 30 cases in each group. Both groups were given nutritional support， to maintain electrolyte balance， three levels of painkiller and anti-infective and other basic treatment. Patients in the treatment group were treated with capecitabine monotherapy， 1250 mg/m2 per time， twice a day， 30 min after dinner， orally， for two weeks and one week off for a chemotherapy cycle， a total of two cycles of chemotherapy. While patients in the treatment group were additionally treated with Chaishao Liujunzi Decoction， 1 dosage per day for morning and evening， for 6 weeks. Followed up for 4 weeks. Efficacy of solid tumor， TCM symptom ef