柴芍二仙汤联合他达拉非片治疗勃起功能障碍40例临床的研究.docVIP

柴芍二仙汤联合他达拉非片治疗勃起功能障碍40例临床的研究 　　摘要：目的观察柴芍二仙汤联合他达拉非片（每日5mg）治疗勃起功能障碍（ED）的临床疗效。方法将80例ED患者随机分为柴芍二仙汤联合他达拉非片组（治疗组）、单用他达拉非片组（对照组），各40例，观察2组治疗前后及停药1个月后随访时国际勃起功能问卷-5（IIEF-5）评分和中医证候评分（TCMSS）的变化。结果治疗组总有效率为95%，对照组为85%，2组比较具有显著性差异（P0.05），随访时，IIEF-5评分及TCMSS与治疗前比较，均无显著差异（P0.05）；与对照组相比，治疗组治疗1个月后及停药1个月后随访时，IIEF-5评分及TCMSS均具有显著差异（P0.05）。结论柴芍二仙汤基于疏肝补肾活血之功，联合他达拉非片治疗ED的效果要明显优于单独服用他达拉非片，两者联合服用能明显提高IIEF-5评分，改善ED患者勃起功能，减轻相关中医证候，具有良好的临床疗效，值得在临床上进一步推广运用。 　　关键词：勃起功能障碍；柴芍二仙汤；他达拉非；肝郁肾虚血瘀证 　　中图分类号：R277.5文献标志码：A文章编号：1007-2349（2017）01-0029-04 　　【Abstract】Objective：To observe the clinical curative effect ofChaihao Erxian Decoction combined with tadalafil tablets（5mg daily）on the treatment of erectile dysfunction（ED）patients. Methods：80 ED patients were randomly divided into a Chaiyao Erxian Decoction combined Tadalafil treatment group and a Tadalafil control group，40 cases per group. The changes of IIEF-5 score and TCM Syndrome Score（TCMSS）at 1-month follow-up of the two groups were observed before and after the treatment. Results：The total effective rate of the treatment group was 95% while that of the control group was 85%. There was significant difference between the two groups（P0.05）. In the follow-up visit，there was no significant difference in the scores of IIEF-5 and TCMSS when compared with the pre-treatment between the two groups（P0.05）. When compared with the control group，there were significant differences in IIEF-5 score and TCMSS（P0.05）. Conclusion：Chaihao Erxian Decoction combined with tadalafil tablets has a better effect on the treatment of ED. The combination can obviously improve IIEF-5 score and improve ED patients’ erectile function and reduce the relevant TCM syndromes，worthy of further clinical application. 　　【Key words】erectile dysfunction，Chaishao Erxian Decoction，tadalafil，liver stagnation and kidney deficiency and blood stasis syndrome勃起功能障碍（erectile dysfunction，ED）[1]是指阴茎持续不能达到或维持足够的勃起以完成满意的性生活，病程在3个月以上，为成年男性的常见病，即中医所谓“阳痿”。目前中医治疗勃起功能障碍（阳痿）有从脏腑论治者，有从病因论治者，有从证候论治者，有分龄而治