21基因检测复发风险评分对激素受体阳性早期乳腺癌的治疗决策导向分析.PDFVIP

宀崡鐜颁唬涓村簥澶栫2017骞?鏈堢17鍗风3鏈烲ingnanModernClinicsinSurgery锛孞un.2017锛孷ol.17No.3 305 21鍩哄洜妫€娴嬪鍙戦闄╄瘎鍒嗗婵€绱犲彈浣撻槼 鎬ф棭鏈熶钩鑵虹檶鐨勬不鐤楀喅绛栧鍚戝垎鏋愶紙闄?9 渚嬬梾渚嬫暟鎹垎鏋愶級 鍏冲仴鍗 鍛ㄦ瘏 鏋楀皬浣 榛勬枃淇 鍒樹粊鏂? 1 1 1 2* 庐 銆愭憳瑕併€ 鐩殑 鍒濇鍒嗘瀽21鍩哄洜妫€娴嬪鍙戦闄╄瘎鍒嗭紙recurrencescore 锛孯S锛夊婵€绱犲彈浣撻槼鎬 鏃╂湡涔宠吅鐧岀殑娌荤枟鍐崇瓥瀵煎悜浣滅敤銆傛柟娉 2016骞?鏈堣嚦2017骞?鏈堜簬姹熼棬甯備腑蹇冨尰闄㈡櫘閫氬绉 浣忛櫌骞惰鎵嬫湳娌荤枟鐨勬縺绱犲彈浣撻槼鎬ф棭鏈熶钩鑵虹檶鎮ｈ€?9渚嬶紝鎸夌収21鍩哄洜妫€娴嬪鍙戦闄╄瘎鍒嗙粨鏋 鍒嗘垚浣庡嵄缁勪笌涓?楂樺嵄缁勶紝姣旇緝鍏朵复搴婄梾鐞嗙壒寰佸強璇勫垎鍓嶅悗鐨勬不鐤楀喅绛栥€傜粨鏋 鍦ㄦ偅鑰呯殑涓村簥鐗 寰佷笌RS澶嶅彂鍒嗘暟鐨勫叧鑱旀€у垎鏋愪腑鎻愮ず锛屽鍙戦闄╁垎缁勪笌骞撮緞銆佺粷缁忕姸鎬併€佽偪鐦ょ洿寰勩€佺梾鐞嗙粍缁囧 鍒嗙骇鍙婅剦绠＄檶鏍撶瓑鍧囨棤鏄庢樉鐩稿叧锛岃€屼笌Ki鈦?7鐨勮〃杈撅紙P=0.027锛夋湁鍏炽€傚湪琛?1鍩哄洜妫€娴嬪墠锛屽叡鏈 18渚嬶紙62.0%锛夋偅鑰呮帹鑽愬唴鍒嗘硨娌荤枟鑱斿悎杈呭姪鍖栫枟锛涘叕甯僐S澶嶅彂鍒嗘暟鍚庯紝11渚嬶紙37.9%锛夋偅鑰呰鎺ㄨ崘 鏀瑰彉涓哄崟绾唴鍒嗘硨娌荤枟锛?渚嬶紙24.1%锛夋偅鑰呬粛寤鸿琛岃緟鍔╁寲鐤楋紙McNemar鈥檚test锛孭=0.001锛夈€傜粨璁 瀵逛簬婵€绱犲彈浣撻槼鎬ф棭鏈熶钩鑵虹檶鎮ｈ€咃紝澧炲姞21鍩哄洜妫€娴嬪苟璁＄畻澶嶅彂椋庨櫓璇勫垎鑳芥樉钁楁敼鍙樻不鐤楀喅 绛栵紝闄嶄綆涓嶅繀瑕佺殑杈呭姪鍖栫枟鐨勬瘮渚嬨€ 銆愬叧閿瘝銆 鏃╂湡涔宠吅鐧岋紱婵€绱犲彈浣撻槼鎬э紱21鍩哄洜锛涘鍙戦闄╄瘎鍒嗭紱娌荤枟鍐崇瓥 涓浘鍒嗙被鍙凤細R737.9 鏂囩尞鏍囪瘑鐮侊細A doi锛?0.3969/j.issn.1009鈦?76X.2017.03.013 Theutilityof 21鈦僩enerecurrencescoreassayintreatmentdecisionsforwomenwithhormonal鈦 receptorpositiveearlybreastcancer GUANJianhua锛孼HOUYi锛孡INXiaojia锛孒UANGWenjun锛孡IU Renbin. 1DepartmentofGeneralSurgery锛孞iangmenCentralHospital锛孞iangmen 529030锛孋hina锛汥epart鈦? mentofThyroidandBreastSurgery锛宼heThirdAffiliatedHospital锛孲unYat鈦僺enUniversity锛孏uangzhou 510630锛孋hina.Correspondingauthor锛歀IURenbin锛 銆怉bstract銆 Objective Toanalysestheutilityof 21鈦僩enerecurrencescoreassayintreatment decisionsforwomenwithhormonal鈦價eceptorpositive 锛圚R+锛塧ndHER2鈦僥arlybreastcancer 锛圗BC锛? Methods Atotalof 29 femalepatientswithHR+EBCwhohadbeenhospitalizedinJiangmenCentral Hospital锛宖romJanuary 2016 toJanuary 2017锛寃eredividedintolowriskgroupandintermediate/high risk group according to the recurrence score. The general clinical pathological characteristics and the treatment recommendations before and after 21鈦僩ene recurrence score as