黄芪注射液佐治小儿原发性肾病综合征58例的的疗效观察.docVIP

黄芪注射液佐治小儿原发性肾病综合征58例的的疗效观察 　　[摘要] 目的：探究黄芪注射液治疗小儿原发性肾病综合征（PNS）的临床疗效。方法：将2005年1月~2011年1月我院收治的PNS患儿115例随机分为治疗组（58例）和对照组（57例），两组患儿均给予常规治疗。治疗组在常规治疗基础上，加用黄芪注射液治疗3个疗程，共治疗2个月。结果：治疗组患儿在治疗4周后69.0%患儿尿蛋白转阴，治疗8周后91.4%患儿尿蛋白转阴，与对照组比较，差异均有统计学意义（均P＜0.05）；低蛋白血症恢复，治疗组在治疗4周后72.4%患儿恢复正常，治疗8周后94.8%患儿恢复正常，与对照组比较，差异均有统计学意义（均P＜0.05）；胆固醇恢复，治疗组在4周后36.2%患儿恢复正常，8周后82.8%患儿恢复正常，与对照组比较，差异均有统计学意义（均P＜0.05）；在水肿消退、少尿消失、血压恢复、血尿消失、血肌酐和尿素氮恢复方面，两组比较差异无统计学意义（P＞0.05）。结论：黄芪有助于尿蛋白转阴、血浆蛋白和胆固醇恢复。 　　[关键词] 黄芪；治疗；小儿原发性肾病综合征 　　[中图分类号] R725 [文献标识码] A [文章编号] 1673-7210（2012）01（a）-100-02 　　 　　Observation of curative effects on Astragalus Injection in the treatment of 58 children with primary nephrotic syndrome 　　ZHANG Ping 　　Department of Paediatrics, the Third Peoples Hospital of Anyang City, Henan Province, Anyang 455000, China 　　[Abstract] Objective: To explore the clinical efficacy of Astragalus Injection in the treatment of children with primary nephrotic syndrome (PNS). Methods: 115 children with PNS admitted and treated in our hospital from January 2005 to January 2011 were randomly divided into the treatment group (58 cases) and the control group (57 cases). All the children of the two groups were given conventional treatment. Children of the treatment group were given additional Astragalus Injection in the treatment for 3 treatment courses, lasting for 2 months on the basis of conventional treatment. Results: In the treatment group, the urine protein of 69.0% children turned negative within 4 weeks of treatment and 91.4% within 8 weeks, with significant differences compared with the control group (P0.05). Conclusion: Astragalus helps urine protein in turning negative, plasma protein recovery and cholesterol recovery. 　　[Key words] Astragalus; Treatment; Children with primary nephrotic syndrome 　　 　　小儿原发性肾病综合征（primary nephritic syndrome, PNS）大约占儿童期肾病综合征总数的90%，原发肾损害使肾小球通透性增加，导致蛋白尿而继发低蛋白血症、高胆固醇血症、水肿等一系列病理生理改变。单纯西药治疗效果不佳，笔者探讨中药在小儿PNS治疗中的作用，选用黄芪注射液佐治58例PNS患儿，观察其在降低蛋白尿、恢复血浆蛋白和胆固醇方面的作用，明显优于单纯西药组，取得较好疗效，现报