急性孤立性远端深静脉血栓抗凝治疗效果剖析.docVIP

急性孤立性远端深静脉血栓抗凝治疗效果剖析 　　[摘要]目的 观察利伐沙班和华法林治疗急性孤立性远端深静脉血栓的效果及安全性。方法 选取2015年7月～2016年9月在我院就诊的103例急性孤立性远端深静脉血栓患者，根据治疗方法的不同分为利伐沙班组（48例）和华法林组（55例），分别采用利伐沙班和华法林治疗。所有患者均治疗至少3个月，随访观察两组治疗后效果及安全性。结果 利伐沙班组和华法林组治疗急性孤立性远端深静脉血栓效果相当，但利伐沙班组的栓塞静脉完全再通时间与华法林组比较，差异无统计学意义（P0.05）。利伐沙班组的出血事件及停药事件发生率低于华法林组，差异有统计学意义（P0.05）。结论 利伐沙班和华法林治疗急性孤立性远端深静脉血栓效果均较好，利伐沙班是华法林有效和安全的替代，更安全、方便，特别对于门诊患者。 　　[关键词]华法林；利伐沙班；孤立性远端深静脉血栓；抗凝药；治疗 　　[中图分类号] R973+.2 [文献标识码] A [文章编号] 1674-4721（2017）09（b）-0126-04 　　Analysis on effect of anticoagulation therapy in patients with acute isolated distal deep vein thrombosis 　　WANG Ping-jiao1 WANG Wen-ming2 CUI Guang-he3 CHEN Gang2 　　1.Binzhou Medical University，Shandong Province，Binzhou 256600，China；2.Department of Interventional Vascular Surgery，Affiliated Hospital of Binzhou Medical University，Shandong Province，Binzhou 256600，China；3.Department of Ultrasound，Affiliated Hospital of Binzhou Medical University，Shandong Province，Binzhou 256600，China 　　[Abstract]Objective To observe the efficacy and safety of Rivaroxaban and Warfarin in the treatment of acute isolated distal deep vein thrombosis.Methods From July 2015 to September 2016，103 cases of acute isolated distal deep vein thrombosis in our hospital were selected and divided into the Rivaroxaban group （48 cases） and Warfarin group （55 cases） according to the different treatment methods，Rivaroxaban and Warfarin were used for the treatment respectively.All patients were treated for at least 3 months.The efficacy and safety of the two groups were observed after treatment.Results The efficacy of Rivaroxaban and Warfarin in the treatment of acute isolated distal deep vein thrombosis was significant，but there was no significant difference in the complete recanalization time of venous embolism between the Rivaroxaban group and the Warfarin group （P0.05）.The incident rate of bleeding events and drug withdrawal in the Rivaroxaban group was lower than that in the Warfarin group，with significant difference （P0.05）.Conclusion Ri