长春西汀联合依达拉奉治疗脑梗死后血管性认知障碍疗效剖析.docVIP

长春西汀联合依达拉奉治疗脑梗死后血管性认知障碍疗效剖析 　　[摘要] 目的 ?^察脑梗死后血管性认知障碍者临床使用依达拉奉、长春西汀治疗的有效性。 方法 选取我院2014年7月～2016年10月期间收治的84例脑梗死后血管性认知障碍者，按随机排列表法分为两组，其中对照组41例（应用依达拉奉）、观察组43例（加用长春西汀）。疗程结束后对患者智能状态、认知功能进行评分并与治疗前进行比较，评估患者神经功能缺损情况以及预后情况，观察两组患者认知障碍治疗效果，统计治疗期间不良事件发生情况。 结果 观察组不良事件发生率为4.7%，与对照组的2.4%比较，组间差异无统计学意义（P0.05）；智能精神状态检查量表（MMSE）、蒙特利尔认知评估表（MoCA）评分入院时两组差异无统计学意义（P0.05），用药后观察组评分高于对照组（P0.05），治疗后两组评分均有明显降低，且疗后7 d、1个月研究组评分低于对照组（P0.05）；观察组总有效率为95.3%，相比于对照组的85.4%，观察组治疗效果更佳（P0.05）；治疗后7 d、1个月研究组mRS低于对照组（P0.05）。 结论 脑梗死后血管性认知障碍者临床以依达拉奉、长春西汀联合治疗，患者认知障碍、神经功能、智能状态改善明显，临床治疗效果理想、预后情况好、用药安全性高。 　　[关键词] 长春西汀；脑梗死；依达拉奉；血管性认知障碍 　　[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2018）01-0100-04 　　Analysis of curative effect of vinpocetine combined with edaravone in the treatment of vascular cognitive impairment after cerebral infarction 　　ZHANG Chao1 LI Yong’ang1 YE Zhinan2 YE Junqiang1 RAO Gaofeng3 　　1.Department of Neurology， Wenling First People’s Hospital in Zhejiang Province， Wenling 317500， China； 2.Department of Neurology， Taizhou Municipal Hospital in Zhejiang Province， Taizhou 318000； 3.Department of Rehabilitation， Wenling First People’s Hospital in Zhejiang Province， Wenling 317500， China 　　[Abstract] Objective To observe the efficacy of clinical application of edaravone and vinpocetine in the treatment of vascular cognitive impairment after cerebral infarction. Methods A total of 84 patients with vascular cognitive impairment after cerebral infarction who were admitted to our hospital from July 2014 to October 2016 were selected as the study subjects. The patients were divided into two groups according to the random number table method. There were 41 patients in the control group（administration of edaravone）， and there were 43 patients in the observation group （combined administration of vinpocetine）. After the end of treatment， the patients intelligence status and cognitive function were scored and compared with those before treatment. Neurological deficits and prognosis of patients were evaluated，