非小细胞肺癌患者放射治疗后放射性肺损伤及预后的预测分析-肿瘤学专业论文.docx

华中科技大学博士学位论文 华 中 科 技 大 学 博 士 学 位 论 文 PAGE 10 PAGE 10 第二部分的假设是 TGFβ1 基因的功能性变异可能影响肺癌的进展，它们可能是预测 预后有效的分子指标。为了验证这一假说，我们检测了 TGFβ1 基因 3 个区域的单核 苷酸多态性 (single nucleotide polymorphisms ， SNPs) ， rs1800469, rs1800471, and rs1982073；回顾性分析了接受了特定放（化）疗的 NSCLC 患者的这些 SNPs 与总生 存时间、无进展生存时间、无远处转移生存时间和无脑转移生存时间的关系。 既然炎性细胞因子与放射性肺伤及远处转移之间存在明显的关系，那么放射导致 放射性肺损伤的微环境可能和远处转移间也存在明显的关系。因此，本研究的第三部 分目的是进一步探讨放射性肺损伤分级与接受放射治疗的非小细胞肺癌预后的关系。 参考文献 Jemal A, Siegel R, Ward E,et al: Cancer statistics. CA Cancer J Clin 58:71-96,2008 Kong FM, Ao X, Wang L, et al: The use of blood biomarkers to predict radiation lung toxicity: a potential strategy to individualize thoracic radiation therapy. Cancer Control 15:140-50,2008 Kasai H, Allen JT, Mason RM, et al: TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6:56, 2005 Zhao L, Wang L, Ji W, et al: Elevation of plasma TGF-beta1 during radiation therapy predicts radiation-induced lung toxicity in patients with non-small-cell lung cancer: a combined analysis from Beijing and Michigan.Int J Radiat Oncol Biol Phys 74:1385-90,2009 De Jaeger K, Seppenwoolde Y, Kampinga HH, et al: Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 58:1378-87, 2004 Andreassen CN, Alsner J, Overgaard J, et al: TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol 75:18-21, 2005 De Ruyck K, Van Eijkeren M, Claes K, et al: TGF[beta]1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors. Int J Radiat Oncol Biol Phys 65:1240-1248, 2006 Yuan X, Liao Z, Liu Z, et al: Single nucleotide polymorphism at rs1982073:T869C of the TGF{beta}1 gene Is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol, 2009 Shu XO, Gao YT, Cai Q, et al: Genetic