鲍曼不动杆菌206株临床分布及耐药性研究.docVIP

鲍曼不动杆菌206株临床分布及耐药性研究 目的：了解鲍曼不动杆菌菌株分布及对常用抗菌药 物的耐药性。方法：分析2008年11月?2010年12月常规 细菌培养分离的鲍曼不动杆菌的分布情况及其耐药性，并采 用Whonet5. 4软件进行统计分析。结果：检出的206株鲍曼 不动杆菌中，以痰液及咽拭子分离率较高（80.1%），临床分 布以呼吸肿瘤和ICU为主（77.2%）。鲍曼不动杆菌对17种 常用抗菌药物的耐药率以舒普深最低，对其余抗菌药物的耐 药率均在20%以上，甚至对亚胺培南的耐药率也达27.3%。 206株鲍曼不动杆菌中，有23株为泛耐药菌株。结论：鲍曼 不动杆菌对17种常用抗菌药物存在不同程度的耐药性，应 加强鲍曼不动杆菌的耐药性监测，为临床合理选用抗菌药物 提供依据。同时应对泛耐药鲍曼不动杆菌采取有效的预防措 施，避免泛耐药菌株的暴发流行。 关键词鲍曼不动杆菌临床分布耐药性暴发流行 AbstractObjective：To investigate the clinical distribution of Acinetobacter baumannii and to understand the frequently-used antimicrobial resistance in our hospital. Methods：Collected 206 strains Acinetobacter baumannii which were conventional bacterial culture from November 2008 to December 2010 In our hospital,analyzed their clinical distribution and drug resistance. The results were analyzed by Whonet 5. 4 software. Results： A total of the 206 strains Acinetobacter baumannii isolated,80. 1% were from sputum and throat swab. The clinical distribution in the department of respiratory cancer and ICU-based together account for 77. 2%. In the drug resistance rates of Acinetobacter baumannii to 17 frequently-used antimicrobial,the lowest was to Sulperazon and the other was over 20%,the drug resistance rate to imipenem even also achieve 27. 3%. In 206 strains Acinetobacter baumannii,23 strains were extensively drug-resistant strains. Conclusion：Acinetobacter baumannii to 17 frequently-used antibiotics exists different degree of resistance. In order to provide the basic evidence for reasonably,weclinical selectsing the antibiotics should strengthen monitoring the drug resistance of reasonably,we Acinetobacter baumannii. Meanwhile we should take effective preventive measures to the Acinetobacter baumannii of pan-bearing the drugs to avoid it outbreaks. distribution；drug resistance；outbreaks 不动杆菌属为一群不发酵糖类、氧化酶阴性、不能运动 的革兰氏阴性杆菌，其广泛分布于自然界和医院环境中。在 临床标本中，最常见的是鲍曼不动杆菌，它是仅次于铜绿假 单孢菌而居临床分离阳性率第二位的非发酵菌［1］。由于本 菌能够获得多重耐药性且能够在大多数环境中生存，目前由 本菌引起的医院内感染呈现增加趋势。当其侵袭免疫力低下 的患者时可以造成严重甚至致死性的感染，如肺炎、尿路感 染、