儿童过敏性紫癜肾损伤相关临床危险因素分析及血液灌流保护肾脏的疗效评估儿科学专业论文.docxVIP

西南医科大学硕士学位论文The 西南医科大学硕士学位论文 The analysis of the clinical risk factors caused kidney injure in children with Henoch-Schfinlein purpura and effect evaluation of kidney protection in such patients received hemoperfusion [Abstract]：Objective：(1)To explore the clinical risk factors caused kidney injure in children with Henoch-Sch6nlein purpura,SO to take intervening measures early for children with such risk factors in clinical work to find and treat their kidney injures to improve their prognosis and increase their life quality．(2)To investigate the curative effect of kidney protection in children with Henoch-Sch6nlein purpura received hemoperfusion(HP)whose urine tests were normal before HP．Methods： All the 1 73 patients were followed up for more than 1 year and they were divided into kidney injure group(5 7cases)and non-kidney injure group (1 1 6 cases)by their urine tests results．The variants of gender,age， clinical manifestations，the platelet count in peripheral blood and the fibrinogen level，the results of urine tests were made single factor analysis and multiple logistic regression analysis．Among 1 73 cases with Henoch-Sch6nlein purpura whose urine tests showed normal，1 25 severe cases were divided into two groups：56 cases in treatment group received hemoperfusion and traditional treatment．69 cases in control group got only traditional treatment．Results：1．By the single factor analysis， gastrointestinal bleeding，skin rashes repeated三3 times，skin rashes lasting1 month showed statistical significance between the kidney ．3． 万方数据 injure蓼oup injure蓼oup a11d non-kidney injure group(P-0．002、1．389×10一、 7．07 4×1 0—6)．2．The multiple Logistic regression analysis showed妇 rashes repeated≥3 times，skin rashes lasting1 month were closelY related to kidney injure(旷3．703×10。4、0．009；OR=3·941、3．915)。3· with 1 6．1％in treatment group and 49．3％in control group were found wn kidnev injure by the urine tests during the one year follow。up孤d statistical significanCe(仁1．018×10。40．05)．Conc