PI-3K2fGSK3β信号通路介导心肌营养素-1对心肌细胞缺氧复氧损伤的作用.pdfVIP

Abstract after3h 10min with later,then hypoxia，CT-1(10ng／m1)wasgiven processed for3h． reoxygeonation RESULTS： and 1．Rateand of beated the rhythmcardiomyocytebeat：cardiomyocyteregularly wasabout148beats／minineach before beatingfrequency group hypoxia，there wasno difference．The beated and significant cardiomyocyteslowly,weakly inCT-1 after beats hypoxia-reoxygeonation．Thecardiomyocytegroup irregularly was tothosecontrolaswellasthosebefore similar group beated and atter withblockers However,itslowly，weaklyirregularlyprocessing DNSOcouldnotaffecttheroleof indicates LY294002，while CT-1．Therefore，it thatLY294002could blocktheeffectofCT-1in particularly protecting from cardiomyocytehypoxia-reoxygeonationinjury． and survival rateswere 2．Cardiomyocyteinjury：The apoptosis 96．2±3．2％and incontrol survivalratedecreased to 2．8±O．4％respectivelygroup．The apparently rate to1 76．8+4．6％and increased 9．4+2．3％in apoptosis obviously hypoxia-- Was