硅胶胰肠吻合器的研制及其在动物试验中的应用-材料工程专业论文.docxVIP

万方数据 万方数据 Subject : Preparation of Pancreaticojejunostomy Anastomat based on Methyl Vinyl Silicone Rubber and Application in Animal Living Body Testing Speciality : Materials Engineering Name ：Liang Zhang Instructor: Shuiyuan Shao (Signature) Longgui Peng (Signature) ABSTRACT Pancreaticoduodenectomy is the one and only way to radically cure the cancers of pancreas, bileduct and duodenum. But this procedure is complex and possesses much syndrome, and pancreatic fistula is the one of the most dangerous syndrome. In order to increase the success rate of pancreaticojejunostomy, reduce symdrome and death rate, doctors have increasingly focused on the research of pancreaticojejunostomy. Carrying out the pancreaticoduodenectomy by means of anastomat is one of the important part. In this thesis, a pancreaticojejunostomy anastomat was designed and studied, using methyl vinyl silicone rubber as matrix, benzoyl peroxide as vulcanizing agent, polymethylhydrosiloxane as crosslink agent, gaseous phase silicon dioxide as reinforcing filling, dihydroxydiphenylsilane as structural control agent silica, and quaternary ammonium hydroxide as catalyst agent. Anastomat was prepared the through one step of vulcanization with above materials and pre-embedded titanium nails. Molecular structure of anastomat was investigated with Fourier transform infrared spectroscopy (FTIR). Thermal properties were analyzed by thermal gravimetric analyzer (TGA) and hot air aging testing. Mechanical properties such as tensile strength and break elongation rate were tested also. Chemical corrosion resistance was testing by contacting water, alcohol and dioxygen water. Living body operation was carried out by cutting jejunum, breaking mucous membrane, pancreas setting into the jejunum, anastomat enwrapping anastomosing part, and fixing the anastomat. The position of titanium nails of anastomat was observed by abdomen X ray. Hyperplasia of fibrous tissue between the pancreas and intestines wall