急性高原肺水肿患者血浆气体信号分子硫化氢变化及意义-呼吸病学专业论文.docxVIP

青海大学医学院 青海大学医学院 2010 级攻读临床医学硕士学位研究生毕业论文 PAGE PAGE 10 Changes and significance in expression of plasma hydrogen sulfide in patients with acute high altitude pulmonary edema Abstract Objective：To explore the expression and significance of plasma endogenous hydrogen sulfide (H2S) in patients with acute high altitude pulmonary edema . Method：Determination of plasma H2S content through the use of sensitive sulfur electrode method (PXS-270 type, Leici). There were 38 cases of acute high altitude pulmonary edema (case group) and 35 healthy subjects (control group) into the Yushu area (3600 m above sea level) .Parallel statistical analysis of the data finishing. Statistical methods: SPSS17.0 statistical software for data analysis, the healthy subjects and the patients before and after treatment of plasma H2S all were shown as means ± standard deviation (?x ± s), Between the two groups were compared using analysis of variance. The inspection standard was alpha = 0.05. Results ：1.The results showed there were statistically significant difference of H2S level concentration before and after the treatment of patients with acute high altitude pulmonary edema was（t =8.219, P 0.01), and the patients before treatment with H2S concentration level was slightly lower than the patients after treatment.2.There were statistically significant difference of H2S level concentration with the healthy control group and case group with acute high altitude pulmonary edema（F=188.951, P 0.01)，and the patients before and after treatment with plasma H2S concentration levels lower than the healthy control group. Conclusions ：1.Acute high altitude pulmonary edema plasma H2S concentration lower than the healthy control group.2. Acute high altitude pulmonary edema patients before treatment after treatment plasma H2S concentrations below. Key words：Acute high altitude pulmonary edema（AHAPE) hydrogen sulfide(H2S) 前 言 高原肺水肿(high altitude pulmonary edema，HAPE) 是由于机体对高原 低压性缺氧环境适应不全，而引起肺动脉压突然升