急慢性病理条件下Notch通路调控肠粘膜屏障功能的作用及机制研究-外科学(普外)专业论文.docx

第三军医大学博士学位论文 第三军医大学博士学位论文 万方数据 万方数据 英文缩写 缩略语表 英文全称 中文全称 IBD TPN SIRS MODS I/R MSBR BMP PCNA SBS KGF NICD HIF-1 H/R MAPK TGF-α TGF-β GLP-2 CSL CTBP1 GSK3β inflammatory bowel disease total parenteral nutrition systemic inflammatory response syndrome multiple organ dysfunction syndrome ischemia/reperfusion massive small bowel resection bone morphogenetic protein proliferating cell nuclear antigen short bowel syndrome keratinocyte growth factor notch intracellular domain Hypoxia-inducible factor-1 hypoxia/reoxygenation mitogen-activated protein kinases transforming growth factror α transforming growth factror β glucagon-like peptide-2 CBF1 suppressor of hairless-Lag1 carboxy-terminalbinding protein 1 glycogen synthase kinase 3β 炎症性肠病 全胃肠外营养 全身炎性反应综合征 多脏器功能障碍综合征 缺血再灌注 小肠大部切除术 骨形态发生蛋白 增殖细胞核抗原 短肠综合征 角质细胞生长因子 Notch 受体活性片段 缺氧诱导因子-1 缺氧/复氧 促分裂素原活化蛋白激酶 转化生长因子 α 转化生长因子 β 糖蛋白-2 核结合蛋白 CSL 羧基末端结合蛋白 糖原合成酶激酶 1 Notch signaling involved in the regulation of intestinal barrier function in acute and chronic pathological conditions Abstract Background Intestinal barrier is a protective barrier system against the external environment. In some conditions, such as trauma, burn injury, IBD and TPN, the intestinal barrier was destroyed and lead to SIRS and MODS. Studies have been done to explore the mechanisms about injury and repair of intestinal barrier. However, the precise mechanisms of these processes are still not fully understood. The intestinal epithelium is formed of a single cell layer and it is one of the most important parts of intestinal barrier. Intestinal epithelium supports nutrients and water transport and maintains a defense against bacteria, intraluminal toxins and antigens. The intestinal epithelium is one of the most rapidly proliferating tissues in the body. The intestinal epithelial cells at the top of the villi die and the epithelial cells at the intestinal crypts proliferate to compensate for the lost cells. This process takes generally 4-7 d and it is importan