硫化氢对大鼠急性心肌缺血的影响-药理学专业论文.docxVIP

帅Ill 帅Ill LIlIIIIIIIIIlUlII Illlllll IIIilllltll Y1 80 1 6 1 5 目 录 中文摘要 ··1 英文摘要D O O O ··5 英文缩写··O O ·O O O o ··10 研究论文 硫化氢对大鼠急性心肌缺血的影响 引言O O······················．．．．．．．．．．．．．·················．·．．·．．．1 1 第一部分 急性心肌缺血大鼠内源性硫化氢／胱硫醚一Y一裂解酶体系 的变化 前言····························．··．．．．．．．．．．．．．··．······．．．．．．．刖舌···························································· ·······12．．．．．．．12 材料与方法 ．．12 结果·O O················································．．．．．．．15 附图········································．··．-·········-·····．．．．．．．．．．16 附表·······························································．．．．．．．22 讨论······································．．．．．．···············．．． ．．24 ／J、结····”·······“···········一···．．·．· ．．· · ···．．．．一．．．．．．25 参考文献 ．25 第二部分 硫化氢对心肌缺血大鼠线粒体功能及细胞凋亡的影响 前言．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．7．．．．．．．．．．．．．．．．．．．．．．．．27日IJ舌·-···········································?························2’7 材料与方法 ．-27 结果············ ·-· ················．··．·．．··························32 附图····················O O····································．．·····．．．34 附表······························．·．．．．．．．．．．．．．··．．．．．．．．．．．．．．．．．．．．．．．42 讨论·-················· ．．．．．．．．．．．．．．．．．．．．．．．·．．．．．．．．．．．．．．．．．．．．．．．．45 ／J、结·一·”···”··”·····一一··一·一一．．．．．．．．．一”””．”””“．．．．．．．．．．．47 参考文献 · ．47 结论·····································．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．49 综述 内源性硫化氢与心血管疾病的研究进展 ．．50 致谓十··-·········································．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．61 个人简历 ．62 中文摘要硫化氢对大鼠急性心肌缺血的影响 中文摘要 硫化氢对大鼠急性心肌缺血的影响 摘 要 心肌缺血是指心脏的血液灌注减少，导致心脏的供氧减少，心肌能量 代谢不正常，不能支持心脏正常工作的一种病理状态，严重威胁人类的身 心健康，因而对于缺血心肌保护的研究是倍受