快律宁胶囊抗快速心律失常的离体药效学实验研究-中医内科学专业论文.docxVIP

group was not significant (p 0.05). Comparison group, the propafenone group the APD50, APD90 were longer than the KLN capsules three dose groups (P 0.01). Compared with the control group, the KLN capsule dose-dependent decreases VMAX, which high-dose group decreases, especially (P 0.01). From group showed, the KLN capsules three dose groups with propafenone VMAX had no significant differences (P 0.05). Compared with the control group, the lower the APA the KLN capsules can be a dose-dependent group comparison shows that in the propafenone group APA KLN capsule low dose compared to significant differences in the propafenone group APA lower (P 0.01) compared with the high dose group had no significant difference (P 0.05). The KLN capsule high medium and low-dose group RR interval after treatment were significantly prolonged (P 0.05) and dose-dependent manner. The KLN capsules before and after administration of three dose groups of QT and QTc were no significant difference (P 0.05). After administration of propafenone group, RR interval, the QT interval and QTc were significantly prolonged (P 0.05). Perfusion process, the KLN capsules three dose groups were not induced by the EAD, the propafenone group had four cases of EAD, which statistics EAD had incidence significant difference (P 0.01). Experiment 2: Compared with the control group, the KLN capsule dose-dependent reduction of exogenous free radicals induced of VEB, VT occurrence (P 0.01). The KLN capsule three dose group and verapamil group were not VF control group induced the VF, but no significant statistical difference (P 0.05). Compared with the control group, the KLN high dose group arrhythmia appear later (P 0.05). The KLN capsule medium and low-dose group, verapamil group of arrhythmias also postponed, but statistics had no significant difference (P 0.05). Compared with the control group the KLN capsule three dose groups heart rate slowed down, and was dose-related. And control groups KLN capsule high and