联合应用盐酸右美托咪啶和肢体远程缺血后处理对大鼠局灶性脑缺血损伤的影响-麻醉学专业论文.docxVIP

PAGE PAGE 10 组间对比：R/D 组、R 组、D 组脑梗死体积比显著低于 C 组(P＜0.01)；R 组与 D 组脑梗死体积比对比差异不明显 (P＞0.05)；R/D 组脑梗死体积比显著低于 R 组 (P＜0.01)， R/D 组脑梗死体积比低于 D 组 (P＜0.05) 。 结论： 1.盐酸右美托咪啶缺血后处理和肢体远程缺血后处理对大 鼠局灶性脑缺血损伤均具有一定的保护作用，二者的保护 作用相当； 2.联合应用盐酸右美托咪啶缺血后处理和肢体远程缺血后 处理对大鼠局灶性脑缺血损伤具有明确的保护作用，二者 联合应用的效果进一步提高，可取得增强的神经保护保护 效应。 关键词：缺血/再灌注损伤；神经保护作用；肢体远程缺血后处理； 盐酸右美托咪啶；联合治疗 Combined application of dexmedetomidine hydrochloride and limb remote ischemic postconditioning effect on rats focal cerebral ischemia injury Postgraduate: Wang Yuan The instructor: Li Gang Tutor: Sun Guangyun Abstract Objective: Objective to investigate the effects of limb remote ischemic postconditioning combined with dexmedetomidine hydrochloride (DEX) on the injury focal cerebral ischemia models of SD rats, including the neurological function scores, infarct volume ratios. For the prevention and treatment of stroke, to provide new ideas and ways to reduce the brain damage caused by stroke; at the same time, discuss the clinical study on combined application of various protection mode of the feasibility and availability of neuroprotective effect enhancement. Method: 32 male SD rats, weighing 280 ± 20g, were randomly divided into 4 groups: control group(C), limp remote ischemic postconditioning group(R), dexmedetomidine hydrochloride treatment group (D), combined group (R/D), 8 rats in each group. Animal neurological function score (Longa) of 0 rats were included in the study, the experimental preparation of rat middle cerebral artery occlusion model with nylon thread on method (MCAO). C group: Rats with middle cerebral artery occlusion model (right) were prepared; group R: Rats with middle cerebral artery occlusion model (right) were prepared and treated by left lower extremity remote ischemic postconditioning; group D: Rats with middle cerebral artery occlusion model (right) were prepared and treated by dexmedetomidine; R/D group: Rats with middle cerebral artery occlusion model (right) were prepared ,and treate