多囊卵巢综合症患者不同促排卵方案临床疗效研究.docxVIP

多囊卵巢综合症患者不同促排卵方案临床疗效研究 【摘要】目的：以行体外受精-胚胎移植(IVF-ET) 治疗的多囊卵巢综合症(PCOS)患者为研究对象，分别采用 GnRH激动剂(GnRH-a)长方案(I组)、GnRH拮抗剂(GnRH-A) 方案(II组)进行促排卵治疗，通过两组临床结局的比较， 寻求更适宜PCOS患者的促排卵治疗方案。方法：选择2008 年1月至2010年6月就诊于我院不孕不育专科门诊的62名 多囊卵巢综合症患者，这些患者在我院门诊接受促排卵治疗 后于北京大学人民医院生殖中心接受IVF-ET治疗。根据不 同的促排卵方案将患者分成两组，比较各组患者的基本特 征、Gn用药天数、Gn量、HCG日LH水平、E2水平、获卵数、 受精率、妊娠率、周期取消率、0HSS发生率等。结果：两组 患者Gn剂量差异有统计学意义(P0. 05)；两组患者的HCG 日血清E2水平、LH水平差异有统计学意义(P0.05)。结论: 使用GnRH-A方案有效减少了 IVF-ET的PCOS患者Gn的使用 量，减轻了患者的经济和心理负担，是PCOS患者行VF-ET 较为适宜的促排卵方案。 【关键词】多囊卵巢综合症；GnRH激动剂；GnRH拮抗 剂；体外受精-胚胎移植 Curative effect of different ovulation Simulation scheme for patients with polycystic ovary syndromeWU Xiangchun. Department of Obstetrics and Gynecology, Qinhuangdao Harbor Hospital , Qinhuangdao 066000 , China [Abstract】Objectives： Patients with polycystic ovary syndrome (PCOS) and having received in vitro fertilization - embryo transfer (IVF-ET) treatment were regarded as the research object. 2 schemes, GnRH agonist (GnRH-a) long scheme (group I ) and GnRH antagonists (GnRH~A) scheme (groupII) were adopted to stimulate ovulation, to identify the ovulation simulation scheme more suit able for patients with PCOS through comparing the clinical outcomes of the two groups? Methods： Sixty-two patients with polycystic ovary syndrome came to the Department of Infertility of our hospital between January 2008 and June 2008 were selected. After receiving ovulation Simulation treatment in our hospital, the 62 patients went to the reproductive center of Peking University People s Hospital to receive IVF-ET treatment? According to the different ovulation stimulation scheme adopted , patients were divided into 2 groups. The basic characteristics, number of days taking Gn, amount of Gn, level of LH and E2 on HCG days, number of eggs, fertilization rate , pregnancy rate , cycle cancellation rate and the incidence of OHSS and etc of the two groups were compared. Results： The amount of Gn in the GnRH-A group was lower than GnRH-a long scheme ， demonstrating sig