复方斑蝥胶囊辅助治疗老年淋巴瘤疗效观察.docxVIP

复方斑螫胶囊辅助治疗老年淋巴瘤疗效观察 杨玉兰(河南中医学院第一附属医院 河南郑州450000) 【摘要】目的 观察复方斑螯胶囊辅助治疗老年淋巴瘤疗效观察，分析复方斑螯 胶囊应用的临床价值。方法 将82例符合入组标准的淋巴瘤患者随机分为观察 组41例和对照组41例，对照组进行CHOP方案化疗，21d为一个周期，治疗6 个周期，观察组在对照组基础上，再口服复方斑螯胶囊，每次3粒，bid,连服4 个月。结果 ①观察组总有效率为92.68%,对照组为68.29%,观察组的总有效 率明显高于对照组，差异具有统计学意义，x2二8.083, Plt;0.05；②观察组出现 白细胞减少、肝功能异常、消化道反应、心脏毒性的病例和发牛率分别为 19/46.34% 2/4.88%、15/36.59%、1/2.44%,其中白细胞减少、肝功能异常、消 化道反应的发牛率明显低于对照组，差异均具有统计学意义，Pt;0.05或 Plt;0.01o结论复方螯胶囊辅助治疗老年淋巴瘤值得临床推广。 【关键词】复方斑螯胶囊 老年淋巴瘤 【中图分类号】R273 【文献标识码】B 【文章编号】2095-1752 (2012) 20-0320-02 [Abstract] Objective: To observe the effect of compound cantharidin capsule in the adjuvant treatment of elderly lymphoma, and to analysis the Clinical value of compound cantharidin capsule.Methods: 82 non lymphoma patients met inclusion criteria were randomly divided into 41 cases of observation group and 41 cases of control group, the control group were given CHOP chemotherapy, 21d for a period, treated for six cycles, the observation group were given oral compound cantharidin capsules on the basis of the control group, three each twice daily, and treated for four mon th. Results: ① The total effective rate of the observati on group was 92.68%, the control group was 68.29%, the observation group efficiency was significantly higher, the difference was statistically significant, X2 = 8.083, P lt;0.05; ② The cases and incidenee of leukopenia, abnormal liver function, gastrointestinal reactions, cardiac toxicity were 19/46.34%, 2/4.88,15/36.59%, 1/2.44%,The leukopenia, abnormal liver function, gastrointestinal reactions of the observation group were significantly lower than the control group, the differences were statistically sign ifica nt, P lt;0.05 or P lt;0.01. Con clusi on: Fufang Ban mao capsule the adjuvant therapy for elderly lymphoma worthy of clinical application. 【Keywords］ Compound BanMao capsule The elderly lymphoma 恶性淋巴瘤是临床常见的起源于淋巴造血组织的恶性实体瘤之一，95% 以上为非霍奇金淋巴瘤(NHL),弥漫性人B细胞淋巴瘤(DLBCL)是最常见的亚 型，约占50%以上，其次为慢性淋巴细胞白血病/小淋巴细胞性淋巴瘤和黏膜相关 淋巴组织淋巴瘤，好发于男性，NHL发病可分布各个年龄段