两种带羟基支链冠醚的合成.docxVIP

1 两种带羟基支链冠醍的合成与表征 摘要 自从20世纪60年代发现并合成冠醍之后，冠醍的家族越来越庞大，其种类越发多样，应用领域也越发广泛。带羟基支链冠醍是冠醍中得到重点研究的类型之一，不仅对过渡金属和重金属离子有着特异的配位作用，还可与某些具有特定结构的金属离子进行配位,形成的配合物作为模型分子，为研究生命活动过程提供了广泛的可能性。 为了探究选取的两种带羟基支链冠醍的合成，本实验从设计反应路线到合成条件（温度，反应时间等）进行了探究和改进，主要包括三乙醇胺和三苯基氯甲烷的反应，带保护基N-羟基乙基-18-冠-6-醍的合成和除保护基，丙三醇和三苯基氯甲烷的反应，四甘醇和对甲苯磺酰氯的反应，以及带保护基2-羟基甲基-18-冠-6-醍的合成与除保护基。 合成产率：N-羟基乙基-18-冠6醍的合成产率达到24%, 2-羟基甲基-18-冠-6-醍的合成产率达到28%o 关键词：带羟基，冠醍，合成，表征，产率 Synthesis and characterization of two kinds of branchedhydroxyl crown ethers Abstract Since 1960s, crown ethers was found and synthesized,the family of crown ethersbecome more and more enormous,the kinds of crown ether get into bigger andbigger,the application of crown ethers become more and more huge.Crown ether withhydroxyl branched chain is one of the key research of crown ether.Not only play aspecific coordination role in transition metal and heavy metal ions, but also coordinatewith some specific structure ions.As model molecules,formation of complexesprovides a wide range of possibilities for studying life activity. In order to explore synthesis of two kinds of branched hydroxy crown ethers . Iexplored and improved the expirement from the design of reaction to synthesisconditions (temperature, reaction time and so on) .Including reaction oftriethanolamine and three phenyl methyl chloride, the reaction of synthesis of N-hydroxy ethyl 18-crown-6 ether with protecting group and removing the protectivegroups.reaction of glycerol and triphenyl methane chloride,reaction of tetraethyleneglycol and toluene sulfonyl chloride and synthesis of 2 - hydroxy methyl crown 6ether with protective group and remove of the protecting groups. Synthetic yield:The synthesis rate of N- hydroxy ethyl 18-crown-6 ether was 24%, andthe synthesis rate of 2- hydroxy methyl -6- crown ether was 28%. Key words： hydroxyl, ether, synthesis, characterization, yield TOC \o 1-5 \h \z \o Current Document 开题报告 1 一题目背景和研究意义 1 1.1题目背景 1 \o Current Document 1.2研究意义 1 二国内外研究现