细胞生物学英文课件：细胞连接.pptVIP

复习要点 * * * * * * * 3. plasmodesmata Summary of Cell junction Cell junction and cell adhesion Cell junction cell adhesion Section II Cell adhesion Cell adhesion is the binding of a cell to a surface or substrate, such as an extracellular matrix or another cell. Adhesion occurs from the action of proteins, called cell adhesion molecules (CAMs). Cadherin Selectin IgSF Integrin Molecular structure of CAMs These proteins are typically transmembrane glycoproteins and are composed of three domains: Extracellular domain: interacts either with other CAMs or ECM Transmembrane domain : single-pass Intracellular domain: that interacts with the cytoskeleton Three mechanisms of cell-cell adhesions Homophilic binding Heterophilic binding Linker dependent binding Calcium dependent adhesion molecules Over a dozen different types. Almost all vertebrate cells express one or more cadherins. Single-pass transmembrane glycoprotein composed of about 700-750 residues. 1. Cadherin (1) Molecular structure of cadherin Ca2+ is required to establish cell to cell connection through cadherin Calcium-dependence of Cell Adhesion The cadherin superfamily E-cadherin (epithelial) N-cadherin (neural) P-cadherin (placental) VE-cadherin(vascular endothelial) Cadherin diversity in the central nervous system (2) Function of cadherin Homophilic binding: Cadherins Mediate Cell-Cell Adhesion by a Homophilic Mechanism. Involved in development (formation of tissues and organs) by affect cell differentiation Involved in the Involved in the formation of adhesion belt and desmosome. Selectin are single-chain transmembrane glycoproteins and calcium-dependent binding to sugar polymers. Calcium dependment Heterophilic cell adhesion 2. Selectin (1). Molecular structure of Selectin (2). Function of Selectin Selectins mediate transient interactions between circulating leukocytes and vessel walls at sites of inflammation. (2). Function of Selectin Ig-type domains Calcium-independent Binding mecha