正清风痛宁与雷公藤总苷治疗iga肾病疗效比较.docxVIP

正清风痛宁与雷公藤总昔治疗IgA肾 病疗效比较 【摘要】 目的比较正清风痛宁与 雷公藤总昔治疗IgA肾病的疗效。方法经 肾穿刺活检并结合临床确诊为原发性 IgA肾 病53例，随机分成两组，对照组 23例，服 用雷公藤总昔；治疗组 30例，服用正清风 痛宁。结果对照组与治疗组在研究开始时 各项指标间无统计学差异。治疗 3个月时， 对照组与治疗组24h尿蛋白定量及尿RBC十 数下降比值对比无统计学意义； 但对照组副 作用出现总频数为26% ;而治疗组副作用出 现总频数为10%。结论 雷公藤总昔与正清 风痛宁治疗IgAN,对于肾小球肾炎的蛋白尿 及镜下血尿均有明显疗效，但正清风痛宁较 雷公藤总昔副作用更少。 【关键词】 正清风痛宁；雷公藤总昔片； IgA肾病 Abstract : Objective To compare the curative effects between Zhengqing Fengtongning and multi glycosides of tripterygii on IgA nephropathy (mesangial proliferative glomerulonephritis, MPG). Methods A total of 53 patients with primary IgA nephropathy finally diagnosised by kidney biopsy and clinical characteristics were divided into two groups at random, trial group (n=30) treated with Zhengqing Fengtongning and control group (n=23) treated with multi glycosides of tripterygii. The decreases in 24 hours urinary protein quantitiy and urinary red cell count of were compared between the two There was no statistic difference in each index between the two groups (). After three months treatment, the 24 hours urinary protein quantity and the urinary red cell count decreased both in the control group and the trial group (), without statistic differences between the two groups (). The frequency of the adverse reaction in the control group was 28% and the counterpart was 10% in the trial Both Zhengqing Fengtongning and multi glycosides of tripterygii are the effective drugs for the treatment of urinary protein and hematuria in IgA nephropathy. The frequency of the adverse reaction in the treatment with the former drug is lowerer than that with multi glycosides of tripterygii. Key words : zhengqing fengtongning; multi glycosides of tripterygii; IgA nephropathy IgA肾病在我国属最常见的原发性肾小 球疾病，它的发病率约占原发性肾小球疾病 的30吟40%男女比例约是2: 1,其中大 约20吟30%的病人在发病20年内进展到终 末期肾病［1］。目前临床常用免疫抑制剂环 磷酰胺、骁悉、环抱霉素、雷公藤总昔等治 疗，由于环磷酰胺副作用大，而骁悉及环抱 霉素价格昂贵，多数患者无法接受，2002年 来我科应用正清风痛宁及雷公藤总昔制剂 来治疗IgA肾病53例，疗效满意，现报告 如下。 1资料与方法 病例选择 53例患者均经肾穿刺活检并结合临床 确诊为原发性IgA肾病，以蛋白尿、镜下血 尿为主要表现，肾穿刺病理为肾小球轻 中 度系膜增生，Lee氏分级w I