催化剂分子设计与构思的一些思考教学PPT课件.ppt

However, antibodies lack features that are important for many practical applications, such as thermal stability and chemical robustness. They have a short lifetime and are expensive to produce. A synthetic analogue would be of much interest. Copying their mode of production synthetically is clearly not practical. Molecular-sized cavities can be generated in the solid state by polymerization in the presence of a guest template. This is known as molecular imprinting or “footprint”. MI has attracted considerable attention in the last two decades. On the basis of the shape of the cavity that is similar to that of the template molecule, the materials prepared by this technique have an affinity for the template analogue molecule. A simple approach to generate such a complementary cavity is MI by the use of a removable template. The generation of sites capable of molecular recognition in inorganic and also in polymeric materials is very attractive. Such materials could be used for molecular separation including enantiomeric enrichments and selective sensors, as well as selective catalysts. Molecular Imprinting (MI) 1931, Poljakov found that the pore structure was influenced by the size and shape of the molecules in the gas atmosphere. On a silica gel dried in a benzene adsorbed faster than toluene or xylene. Developments of Molecular imprinting 1949, Dickey prepared for the first time imprinted gels from acidified silica solution in the presence of methyl orange, which, after extraction, adsorbed methyl orange better than a blank gel. 1952, Curti et al. expanded the concept of Dickey to the separation of enantiomers by imprinting silica with an enantiomer. They used a silica gel that was precipitated in the presence of 4-5% of (S)-10-camphorsulfonic acid, and were able to resolve racemic camphorsulfonic acid with an ee of 30%, while with mandelic acid an ee of 10% was reached. A brief look to the development of molecular imprinting related to catalysis research Year M