6 医学微生物学Drug resistance mechanism of bacteria.pdfVIP

Drug resistance mechanism of bacteria •Do you know what bacterial resistance is? How bacteria are resistant to drugs ？ Drug resistance mechanism of bacteria I. Concepts related to bacterial drug resistance. II. Genetic mechanism of bacterial drug resistance. III. Biochemical mechanism of bacterial drug resistance Concepts related to bacterial drug resistance Drug resistance Drug resistance, also known as drug resistance, refers to the relative resistance of bacteria to an antibacterial drug (antibiotic or disinfectant). The degree of drug resistance of bacteria The degree of bacterial resistance is expressed by the minimal inhibitory concentration (MIC) of a drug to bacteria. The so-called MIC refers to the minimum concentration of antibacterial drugs that can block the development of bacteria and be observed after overnight culture. Multiple resistant bacteria It refers to the simultaneous resistance of one microorganism to three classes of antibiotics (such as aminoglycosides, erythromycin, β-lactams) or more than three classes of antibiotics, rather than three of the same class. Cross Resistance After the pathogen is resistant to a certain drug, it can also show resistance to drugs with similar structure or the same nature of action, which is called cross- resistance. According to the different degree, it can be divided into complete cross- resistance and partial cross-resistance. Pan resistant bacteria It refers to bacteria that are resistant to all antibiotics except colistin. Pan- resistance is characterized by resistance to conventional drug sensitivity tests. It mainly includes Pseudomonas aeruginosa, Acinetobacter, Klebsiellaso on. Super resistant bacteria or superbug Superbacteria (superbug) does not refer to a particular kind of bacteria, b