急性白血病患者氧化应激状态与抑郁情绪之间的关系.docVIP

急性白血病患者氧化应激状态与抑郁情绪之间的关系 正文 急性白血病患者氧化应激状态与抑郁情绪之间的关系 文1：急性白血病患者氧化应激状态与抑郁情绪之间的关系 Relatiohip between Oxidative Stress and Depression in Patients with Acute Leukemia AbstractThis study was aimed to investigate the relatiohips between oxidative stress and depression in patients with acute leukemia. Ninety two cases of acute leukemia were randomly enrolled in the study. Depressive disorder was assessed by self-rating depression scales (SDS) and multiple items questionaires. The total anti-oxidation capability (T-AOC), reactive oxygen species (ROS) and superoxide dismutase (SOD) activities, as well as malondialdehyde (MDA) and nitric oxide (NO) levels were measured in pre-treatment periods. Meanwhile, the steady state level of human 8-hydroxyguanine glycosylase（hOGG1）mRNA tracript was monitored by quantitative real-time PCR. The results showed that the defence of antioxidant system was impaired in patients with acute leukemia. The incidence of depression was % in 92 cases. T-AOC and SOD activities were significantly decreased in patients with depression，while ROS, NO, MDA levels and hOGG1 mRNA expression were revee of the former. It revealed that depression positively correlated with coue of disease and hOGG1, and negatively correlated with T-AOC. It is concluded that oxidative damage occu in patients with acute leukemia, moreover, lower antioxidant defences exist in depressive patients. These results undecore the notion that oxidative stress may promote the development of depression. Key wordsoxidative stress; acute leukemia; depression; hOGG1 氧化应激(oxidative stress)是指机体或细胞内氧自由基的产生与清除失衡,导致活性氧(reactive oxygen species, ROS)和活性氮(reactive nitrogen species, R)在体内或细胞内蓄积而引起的氧化损伤过程。近年来研究显示，氧化应激可促进DNA损害、遗传突变等并导致肿瘤发生［1-4］。肿瘤患者普遍存在心身疾病［5-7］，但国内外有关氧化应激状态与肿瘤患者心身疾病关系的报道少见。本研究通过研究初发急性白血病患者血浆中活性氧类物质、抗氧化酶防御系统及DNA氧化损伤修复基因hOGG1的水平，对初发急性白血病患者机体抗氧化状态与抑郁情绪之间的关系做了一些初步分析。 材料和方法 临床资料 92例患者均为2004年3月到2005年7月在西安 交通 大学第二 医院 血液科经骨髓穿刺等检查确诊的急性白血病初发患者，其中男54例，女38例，中位年龄45（19-73）岁。按FAB病理分型：急性非淋巴细胞白血病(ANLL ) 6