骨髓增生性疾病止血功能的研究.docVIP

骨髓增生性疾病止血功能的研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：骨髓增生性疾病止血功能的研究 1 35例患者临床基本资料 5 6例RIPA明显降低患者的血浆vWF:Rco活性分析 6 文2：骨髓增生性疾病致门静脉高压症的诊治 8 1 资料和方法 9 2 结果 9 3 讨论 11 参考文摘引言： 13 原创性声明（模板） 14 文章致谢（模板） 14 正文 骨髓增生性疾病止血功能的研究 文1：骨髓增生性疾病止血功能的研究 Hematostatic Function in Myeloproliferative Diseases AbstractThis study was purposed to investigate the change of early hemostatic funetion in patients with myeloproliferative diseases (MPD) and to explore its significance in combination with clinical data. The platelet aggregative function was measured by using ristomycin,adenosine diphosphate, collagen and adrenine as inducto, the plasma von Willebrand factor-associated antigen (vWF:Ag) level was measured by enzyme-linked immunosorbent assay (ELISA), the plasma von Wellebrand factor-ristomycin cofactor (vWF:Rco) activity was measured in 6 patients with obviously low ristomycin induced platelet aggregation (RIPA). The results showed that the platelet aggregative function obviously decreased in 35 patients, there were distinct differences in maximal platelet aggregative rate between patients and normal controls induced by 4 inducto respectively (P,P,P=,P). There was no obvious difference between patients with MPD and healthy controls in plasma vWF:Ag level (P). Plasma vWF:Rco activity in all 6 patients with MPD chosen was in the normal range,except one patient with essential thrombocytosis (ET) whose plasma vWF:Rco activity was much lower than normal. No correlation was found between platelet count and plasma vWF:Ag level in the patients (r=-). No correlation was found between platelet count and maximal platelet aggregative rate induced by 4 inducto respectively in patients. It is concluded that the occurrence of abnormal platelet aggregative function is high in patients with RIPA and vWF:Rco activity decrease in one patient with ,the shortage of vWF polymer existed in his plasma have needs for further research. No correlation was observed between hemost