小剂量硫酸镁复合芬太尼术后静脉镇痛.docVIP

小剂量硫酸镁复合芬太尼术后静脉镇痛 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：小剂量硫酸镁复合芬太尼术后静脉镇痛 1 1资料与方法 3 13统计学方法 3 文2：小剂量氯胺酮辅助芬太尼用于小儿术后静脉镇痛 5 1 资料与方法 6 2 结果 7 3 讨论 8 参考文摘引言： 9 原创性声明（模板） 11 文章致谢（模板） 11 正文 小剂量硫酸镁复合芬太尼术后静脉镇痛 文1：小剂量硫酸镁复合芬太尼术后静脉镇痛 Abstract： ObjectiveTo investigate the postoperative analgesic effect of fentanyl combined with a small dose of magnesium patients after upper abdominal operation who would undergo postoperative intravenous analgesia were randomly divided into three groups (n=30/group). Group F was administered with μg/kg·h-1 of fentanyl plus 5 mg of droperidol, Group MF1 with fentanyl ( μg/kg·h-1), magnesium sulfate ( mg/kg·h-1) and droperidol (5 mg), and Group MF2 with fentanyl ( μg/kg·h-1), magnesium sulfate (1 mgkg·h-1) and droperidol (5 mg). The drugs in each group were diluted in 100 ml of normal saline and adminisered with a disposable perfusion pump at a speed of 2 ml/h. The static pain scores and the incidences of nausea, vomiting, itching and urinary retention were recorded within the fit 48 hou’ postoperative intravenous analgesia. ResultsThe static pain scores of Group MF1 and Group MF2 during the fit 12 hou were significantly lower than that of Group F (P), but they became similar after 12 hou. The incidences of nausea, vomiting, itching and urinary retention in Group MF1 and Group MF2 were also significantly lower than that of Group F (P). There were no obvious differences in the static pain score and the advee effects between Group MF1 and Group small dose of magnesium sulfate used for postoperative intravenous analgesia can reduce fentanyl requirement, and also reduce the incidences of nausea, vomiting, itching and urinary retention. The analgesic effect of this method is better than that of fentanyl alone. Key words： magnesium sulfate; fentanyl; analgesia PCA(病人自控镇痛，patient control analgesia)是解决术后病人疼痛的有效方法，芬太尼是 PCA最常用、最有效的药物之一，但大剂量的芬太尼可引起病人恶心呕吐、 皮肤瘙痒、 尿潴留等而限制其应用［1~2］。在本研究中笔者观察术后PCA时加用硫酸镁的效果，证实硫酸镁可加强PCA镇痛药的药效，而减少